Activity of plasminogen activator inhibitor-1 in blood of patients with metabolic syndrome depending on a stage of diabetic retinopathy
Journal Title: Офтальмологический журнал - Year 2018, Vol 0, Issue 3
Abstract
Background. The main cause for the development of proliferative diabetic retinopathy (DRP) is the absence of capillary perfusion, resulting in the initiation of retinal neovascularization. In ischemia reperfusion injury of the retina, the plasminogen activator inhibitor 1 (PAI-1), inflammatory mediators, cytokines, adhesion factors activated in the metabolic syndrome (MS) may be involved. Therefore, there is a necessity to evaluate the role of PAI-1 in the initiation and progression of DRP in MS. Purpose. To study the activity of PAI-1 in blood of patients with the metabolic syndrome (MS) depending on a stage of diabetic retinopathy (DRP) and in relation with a level of circulating interleukin-8 (IL-8) and blood fibrinogen. Material and Methods. Studies were carried out in 64 patients (95 eyes) with MS and DRP, comparable in sex, age and duration of type 2 diabetes mellitus (T2DM), which were divided into 3 groups depending on a stage of DRP. The control group consisted of 23 individuals of both sexes with obesity without T2DM. The activity of PAI-1 and the concentration of circulating IL-8 in blood were determined by enzyme immunoassay; fibrinogen was assessed by the clotting method. Statistical analysis included single-factor analysis of variance (ANOVA) and regression analysis. Results. It was shown that only in the case of conditional combination of DRP stages II and III in one stage, the activity of PAI-1 was statistically significantly lower in comparison with the control group ((21.3 ± 2.8 U / ml (95% CI 17.3-25, 3) vs 12.0 ± 3.3 U / ml (95% CI 7.43-16.6), p < 0.05)), which did not occur in DRP stage (p> 0.05). In the group of patients with T2DM, regardless a stage of DRP, the level of PAI-1 activity was positively associated with circulating IL-8 concentration (r = 0.43, R2 = 18.6 %, N = 54, p = 0.001). Also, an inverse linear dependence of blood fibrinogen concentration on the PAI-1 activity was revealed (r = -0.36, R2 = 13.6%, N = 55, p = 0.005). Conclusion. Patients with DRP and MS had significantly decreased PAI-1 at DRP stages II and III compared to non-diabetic obese patients (р<0.05) unlike the patients with DPR stage I (p>0.05); a strong significant positive association between PAI-1 and circulating IL-8 (p=0.001) and a significant negative linear relationship between blood fibrinogen concentration and PAI-1 (p=0.005) were revealed.
Authors and Affiliations
V. Serdiuk, M. Kyryliuk, L. Pylypenko
Keywords
Related Articles
- EP ID EP423622
- DOI 10.31288/oftalmolzh201835256
- Views 92
- Downloads 0
Effect of microprismatic eyeglasses on the character of binocular vision in children with strabismic amblyopia over treatment time
Background: Strabismic children develop early motor and/or sensory complications (amblyopia, poor fixation of the eye, impaired fusion, and impaired binocular vision). The major goals of treatment for strabismic amblyopi...
Clinical and diagnostic value of impairments in electrolyte metabolism in children with acquired myopia
Background: Identifying the biochemical features of the body in myopia associated with connective tissue dysplasia is still important in the ophthalmologist’s practice. Purpose: To assess the clinical and diagnostic val...
Comparison of intravitreal ranibizumab and aflibercept in patients with choroidal neovascularization in pathologic myopia
Purpose. To compare the efficacy of ranibizumab and aflibercept treatment of patients with choroidal neovascularization (CNV) in pathologic myopia. Material and Methods. This was a comparative, uncontrolled, prospective...
Metabolic correction of experimental diabetic retinopathy
Introduction. Diabetic retinopathy (DR) is diagnosed in 50% of the total number of patients suffering from type 1 diabetes mellitus with diabetes duration of over 10 years and in 75-90% of patients with diabetes duration...
Clinical assessment of retinal ganglion cell complex changes in patient groups differing in severity of diabetic polyneuropathy
Background: To our knowledge, no clinical study has previously been performed to investigate changes in the retinal ganglion cell complex (GCC) in diabetes mellitus (DM) patients differing in severity of diabetic polyneu...