ACUTE AND SUB-ACUTE DERMAL TOXICITY STUDIES OF MORINDA CITRIFOLIA L. FRUIT EXTRACT IN SPRAGUE DAWLEY RATS
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2015, Vol 8, Issue 2
Abstract
 Objective: Morinda citrifolia is one of the most significant plants that are used in traditional medicine. However, details of the dermal toxicity of M.citrifolia are still undiscovered. The objective of this study is to investigate the in vivo acute and subacute dermal toxicity of ethanolic extract of M.citrifolia fruit extract at doses 2000 and 5000 mg/kg in acute and 500, 1000 and 2000 mg/kg body weight in rats.Methods: In acute experiment, a total of 40 female rats were divided into eight groups, each group had five rats, and a total of 66 male rats weredivided into 11 groups of six rats in sub-acute experiment.Results: The extract at a single dose of 2000 and 5000 mg/kg of body weight did not produce treatment-related signs of toxicity or mortality inany of the animals tested during the 14-day observation period. In the repeated dose 28-day study, the application of 500, 1000 and 2000 mg/kg ofbody weight/day of fruit extract revealed no significant change (p>0.05) in bodyweight, hematological and biochemical parameters compared withthe control group. Similarly, grosspathology and histopathology examinations of liver, spleen, kidneys, and skin did not reveal any morphologicalalteration.Conclusion: Overall, the results recommend that the close application of M. citrifolia fruit extract did not deliver any critically dangerous impact inrats. Subsequently, the concentrate can be employed for pharmaceutical plans.Keywords: Morinda citrifolia, Acute dermal toxicity, Fruit extract, Sub-acute dermal toxicity
Authors and Affiliations
Ali Khairullah Zahi, Hazilawati Hamzah, Hutheyfa S, Mohd Rosly Shaari Shaari, Shanmugavelu Sithambaram, Hemn Hasan Othman
Keywords
Related Articles
- EP ID EP605713
- DOI -
- Views 100
- Downloads 0
STUDY TO COMPARE THE THERAPEUTIC EFFICACY OF N-ACETYL CYSTEINE AND COMBINATION OF N-ACETYL CYSTEINE AND TAURINE IN PROTEINURIA IN DIABETIC NEPHROPATHY
Objective: Proteinuria is an established risk factor for progressive damage of kidney. This proteinuria can be effectively controlled by drugs that interrupt the renin–angiotensin–aldosterone system. However, the eff...
IN SILICO STUDIES FOR VARIOUS ANTIBACTERIAL BENZIL AND ITS SUBSTITUTED ANALOGS
Objective: The antibacterials have moved on to low levels by more challenges toward antibacterial discovery of drug over an earlier period of 30 years. The resistance pathogens such as Staphylococcus aureus, Mycobacteriu...
“EVALUATION OF GALPHIMIA GLAUCA STEM METHANOL EXTRACT FRACTIONS FOR ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES”
Objective: This current investigation assesses in vivo central and peripheral analgesic effects and anti-inflammatory properties of fractions obtained from Galphimia glauca (GG) stem methanol extract. Methods: The labor...
PHYTOCHEMICAL CONSTITUENTS OF THE ROOT OF BERBERIS MICROPHYLLA
Objective: To objective of this work was to perform phytochemical qualitative and quantitative analyzes of the main secondary metabolites in the root of Berberis microphylla.Methods: The extracts of B. microphylla root w...
CARDIOPROTECTIVE EFFECTS OF ETHANOLIC LEAF EXTRACT OF IPOMOEA BATATAS ON DOXORUBICIN INDUCED CARDIOTOXICITY IN RATS
 Objective: This study was aimed to investigate the protective effects of ethanolic leaf extract of Ipomoea batatas (EEIB) on doxorubicin (DOX)induced cardiotoxicity using Albino Wistar rats by monitoring the enzymatic,...