Acute and Sub Chronic Oral Toxicity Study of Linkus (EMA), Plantain Syrup and AltheaSH Tablet in Mice
Journal Title: RADS Journal of Pharmacy and Pharmaceutical Sciences - Year 2018, Vol 6, Issue 1
Abstract
Objectives: The present preclinical investigation was conducted with the aim to acknowledge the safety of three polyherbal formulations Linkus syrup (EMA), Plantain syrup and AltheaSH tablet extract by evaluating the acute and sub chronic oral toxicity studies in mice. Methods: To determine acute toxicity mice were given individually the doses of 1 or 5 g/kg orally of Linkus syrup (EMA), Plantain syrup and AltheaSH tablet extract. For executing sub chronic oral toxicity, the formulations were given in doses of 50, 100 and 200 mg/kg of body weight for 28 days period. Results: All three polyherbal formulations under test were not found to be the reason of mortality in animals at the administered doses of 1 or 5 g/kg. Further toxicity signs including loss of hairs, lacrimation, weight reduction, gait, tremors and drowsiness were not detected. Conclusion: The current investigation provided confirmation of good tolerance of formulations under test and lack of harmful effects on the functions of the vital body organs of mice in acute and sub chronic oral toxicity analysis. Future prospects will be the conduction of clinical trials of the formulations as the clinical efficiency is verified in preclinical studies.
Authors and Affiliations
Khan Usmanghani
Keywords
Related Articles
- EP ID EP604377
- DOI -
- Views 159
- Downloads 0
Synthesis of 8-Quinolinol Mannich Reaction Products
Objective: To synthesize biologically significant molecules applying Mannich reaction conditions. Method: Equimolar quantities of corresponding aldehydes and amines were mixed with 8-quinolinol (8-HQ) in absolute ethano...
Utilization of Essential Oil in Manufacturing of Different Types of Balm
Background:Despite of great improvements and advancements in the amenities of life, alternative medicine’s trends is increasing day by day. It is obvious that all plants are significantly potent as well as effective with...
Prevalence of Hirsutism in The Islamia University Bahawalpur, Pakistan
Objective: Population based studies on hirsutism, variability with age and distribution, their associated symptoms are limited in Pakistan. Knowledge on the awareness about hirsutism, variability and their associated sym...
Depression Among Islamic Seminaries Students: A Cross Sectional Survey
Objective: Assess the magnitude of depression among students of Islamic seminaries (Madaris). Method: This cross-sectional descriptive study is conducted from October to December 2017. 321 students of Madaris in Karachi...
Extraction and Preliminary Phytochemical Analysis of Different Extracts of Cassia Fistula Linn. Pods
Aims and Objectives: The presence of active chemical compounds in natural sources can help to target plants for their therapeutic activities. Here, chemical scrutiny of Cassia fistula through phytochemical testing was p...