Acute basophilic leukemia
Journal Title: Αρχεία Ελληνικής Ιατρικής - Year 2015, Vol 32, Issue 6
Abstract
A 71-year-old man with a 1-year history of fatigue, weakness, recurrent cutaneous plaques and severe bone pain mainly along the spine (lumbar region and shoulders bilaterally) was admitted to our Department. Laboratory examinations at that moment showed anemia and multiple gastric ulcers following gastroscopy. On examination he was pale, with mild hepatosplenomegaly, multiple small lymph nodes, cutaneous plaques (violaceous, raised, non tender) in the skin of the arms, the legs and the back (figures 1, 2). His hematological tests revealed a normocytic normochromic anemia (Ht: 28.9%, Hb: 9.5 g/dL, WBC 5.100/μL [neutrophils: 43%, lymphocytes: 36%, basophils: 1%, monocytes: 1%, blasts: 19%] (some of them contained large granules) (figures 3, 4), and erythroblasts 8/100 cells) and PLT 45.000/μL. The erythrocyte sedimentation rate was 135 mm/1h. Coagulation studies were normal. His biochemical tests were: BUN 65 mg/dL, creatinine 2.2 mg/dL, SGOT 39 IU/L, SGPT 34 IU/L, LDH 1,376 IU/L, ALP 153 IU/L, γ-GT 39 IU/L, Na+ 140 meq/L, K+ 4.5 meq/L, Ca++ 6.2 mg/ dL, serum total proteins 9.9 g/dL (albumin: 4 g/dL, globulins: 5.9 g/dL). The serum protein electrophoresis revealed a very small spike in the area of α-globulins. The aspiration of bone marrow was dry tap and some smears were obtained from the material of the biopsy showed infiltration of blasts (figures 5–7) [MPO (fig. 8), PAS (figures 9, 10), and NSE (fig. 11)]. The blasts expressed CD33 (36%), CD13 (21%), and CD15 (18%). The cytogenetic and molecular study for Ph1 and bcr/abl were negative. The patient obtained CR with vincristine-prednisolone treatment with simultaneous H2-recepror antagonists.
Authors and Affiliations
J. ASIMAKOPOULOS, L. PAPAGEORGIOU, V. TELONIS, A. ZANNOU, P. ARAPAKI, T. GIANNIKOS, E. NIKOLAOU, G. DRYLLIS, I. KONSTANTINOU, M. ANGELOPOULOU, K. KONSTANTOPOULOS
Keywords
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