Analgesic and anti-inflammatory effects of Toona Ciliata in laboratory animals
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2017, Vol 6, Issue 4
Abstract
Toona ciliata is popularly used as herbal remedy for various ailments. But the scientific basis for its medicinal use especially in pain and inflammation remains unknown. Therefore, the present study was aimed to investigate the analgesic and anti-inflammatory effects of the leaves of Toona ciliata in laboratory animals. The ethanol extract of the leaves of Toona ciliata was used to investigate the acute effect on analgesia by Hot-plate test in mice and on inflammation in rats using carrageenan-induced rat paw edema model. The extract showed a significant (p<0.06) dose dependent increase in reaction time in mice in the hot-plate test at the doses of 250 and 500 mg/kg body weight. The extract also exhibited promising anti-inflammatory effect as demonstrated by statistically significant (p<0.06) inhibition of paw volume by 43.33% at the dose of 500 mg/kg body weight at the fourth hour of study. This study suggests that the ethanol extract of Toona ciliata have both analgesic and anti-inflammatory activity in a dose dependent manner which supported its use as an analgesic and anti-inflammatory drug in folk medicine. This plant may be a useful source of lead components in the treatment of pain and inflammation.
Authors and Affiliations
Dr. Sam Pavan Kumar Gandamalla
Keywords
Related Articles
- EP ID EP412852
- DOI -
- Views 96
- Downloads 0
Quality by design approach to analytical method development for simultaneous estimation of ibuprofen and famotidine in their combined dosage form by RP-HPLC method
This article aims to explain the steps for application of quality by design (QbD) concept to analytical method development and validation, by using an example of simultaneous determination of Famotidine and Ibuprofen in...
Metformin v\s glibenclamide: initial therapy of 2 types of diabetes mellitus in the tertiary care hospital, a comparative study,for effciacy and tolerability.
Background Diabetes mellitus is one of the most common non-communicable disease world-wide. There are many groups of drugs available for the treatment of type 2 diabetes mellitus. we use so many drugs as monotherapy or...
Translational Pharmacology: New approach of drug discovery
Increasingly, the field is recognizing the need to enable a closer collaboration of industry and academia to create a more efficient system for developing new drugs. In parallel with this, the world of drug discovery ha...
Triphala an innovative medicine of the centuries
TRIPHALA had been described from the Era of Charak and Sushruta as a medicine with multiple properties. The drug Triphala is a combination of fruits of Terminalia chebula Retz, Terminalia bellirica Roxb and Emblica offic...
Evaluation of pharmacology teaching-learning methods in a government medical college
The primary objective of this study is to evaluate students’ knowledge and attitude on the various teaching methods and evaluation methods in pharmacology. A cross-sectional study was carried out in a tertiary care teac...