Analgesic and anti-inflammatory effects of Toona Ciliata in laboratory animals
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2017, Vol 6, Issue 4
Abstract
Toona ciliata is popularly used as herbal remedy for various ailments. But the scientific basis for its medicinal use especially in pain and inflammation remains unknown. Therefore, the present study was aimed to investigate the analgesic and anti-inflammatory effects of the leaves of Toona ciliata in laboratory animals. The ethanol extract of the leaves of Toona ciliata was used to investigate the acute effect on analgesia by Hot-plate test in mice and on inflammation in rats using carrageenan-induced rat paw edema model. The extract showed a significant (p<0.06) dose dependent increase in reaction time in mice in the hot-plate test at the doses of 250 and 500 mg/kg body weight. The extract also exhibited promising anti-inflammatory effect as demonstrated by statistically significant (p<0.06) inhibition of paw volume by 43.33% at the dose of 500 mg/kg body weight at the fourth hour of study. This study suggests that the ethanol extract of Toona ciliata have both analgesic and anti-inflammatory activity in a dose dependent manner which supported its use as an analgesic and anti-inflammatory drug in folk medicine. This plant may be a useful source of lead components in the treatment of pain and inflammation.
Authors and Affiliations
Dr. Sam Pavan Kumar Gandamalla
Keywords
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