ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF ROOTS OF ICHNOCARPUS FRUTESCENS

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ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF ROOTS OF ICHNOCARPUS FRUTESCENS

Journal Title: Pharmacologyonline - Year 2008, Vol 1, Issue 1

Abstract

The effect of methanolic extract of Ichnocarpus frutescens (MEIF) was evaluated for its anti-inflammatory activity by using on carrageenan, and cotton pellet induced granuloma tests for its effect on acute and chronic phas e inflammation models in rats, as well as analgesic activity in mice. Dose of 300 mg/kg MEIF and Indomethacin could block the writhing response by 57.54 % and 73.73 % (p < 0.05), respectively. It was also indicated that the MEIF showed significant (p < 0.05) antinociceptive action in hot plate reaction time method in mice. Maximum inhibition (54.63 %) was obtained at the dose of 100 mg/kg after 3 h of drug treatment in carrageenan induced paw oedema, whereas indomethacin produced 57.65 % of inhibition. In the chronic m odel the MEIF 300 mg/kg, indomethacin and dexamethasone standard drug showed decreased formation of granuloma tissue by 22.64, 29.63 % and 34.84 % respectively. The results indicate the potent analgesic and anti- inflammatory effects significant (p<0.05) and therapeutic efficacy of Ichnocarpus frutescens extract on animal models which are comparable with those of standard drugs such as Pentazocine, Indomethacin and Dexamethasone respectively

Authors and Affiliations

A Pandurangan, R L Khosa, S Hemalatha

Keywords

HEPATOPROTECTIVE ACTIVITY OF METHA OLIC EXTRACT OF MADHUCA INDICA ON CARBON TETRA CHLORIDE INDUCED HEPATOTOXICITY IN RATS

The methanol extracts of M.indica studied for hepatoprotective activity against albino rats with liver damage induced by carbon tetrachloride (CCl4). It was found that the methanol extract of M.indica at a dose of 300 mg...

ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF ROOTS OF ICHNOCARPUS FRUTESCENS

EP ID EP151393
DOI -
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