ANTIDIABETIC ACTIVITY OF ROOT OF TERMINALIA CHEBULA ON ALLOXAN INDUCED DIABETIC RAT
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2019, Vol 5, Issue 3
Abstract
The aim of this study was to investigate the Antidiabetic and antihyperlipidemic activities of aqueous and ethanol extracts of roots of Terminalia Chebula in alloxan (ALX) induced diabetic rats. Diabetes was confirmed after 5 days of single intraperitoneal injection of ALX (150 mg/kg) in albino Wister rats. Aqueous and ethanol extracts of roots of Terminalia Chebula (200 and 400 mg/kg) and Glibenclamide (10 mg/kg, p.o.) orally administered daily for 15 days, blood was withdrawn for glucose determination on 0, 1, 10 and 15 days respectively. Five days before the termination of the experiment, the oral glucose tolerance test (OGTT) was performed to assess the glucose tolerance. For this purpose, overnight fasted rats were fed glucose (2 g/kg) orally and blood was collected at 0, 30, 60 and 120 min interval from orbital sinus for glucose estimation. On the15th day, overnight fasted rats were sacrificed and blood was collected for the determination of high density lipoproteins cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), total cholesterol (TC), total glycerides (TG) and total proteins (TP). Aqueous and ethanol extracts of roots of Terminalia Chebula at doses of 200 and 400 mg/kg showed significant reduction is blood glucose, lipid when compared to diabetic control group. We concluded that aqueous and ethanol extracts of roots of Terminalia Chebula possess Antidiabetic and antihyperlipidemic activities. The histopathology study of pancreas was also performed which showed hypoglycemic effect.
Authors and Affiliations
Nasim Akram
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