Apelin-36 and Copeptin Levels in Polycystic Ovary Syndrome
Journal Title: Journal of Infectious Diseases and Treatment - Year 2017, Vol 3, Issue 1
Abstract
he polycystic ovary syndrome PCOS is conventionally defined as a combination of hyperandrogenism and anovulation with polycystic ovaries. In many countries, it represents the leading cause of female infertility. The specific pathophysiology of this syndrome has not yet been established; however it is associated with the presence of insulin resistance, obesity, diabetes mellitus type 2, dyslipidemia, metabolic syndrome, hypertension, cardiovascular disease, hyperplasia and endometrial carcinoma. The studied group consisted of 50 patients with PCOS who were subdivided according to BMI into 2 subgroups (1st with MBI<25 and the 2nd BMI ≥ 25) and 30 apparently healthy women (as a control group and also were divided into 2 subgroups 1st BMI<25 and the 2nd ≥ 25). Lipid profile, fasting insulin level, HOMA-IR, FSH, LH, Prolactin, E2, FT4, TSH, Free testosterone and serum apelin-36 and copeptin were done to all subjects. There were increased in apelin-36 level, copeptin, fasting insulin level, HOMA-IR, LH level, LH/FSH ratio and free testosterone level and lower FSH and E2 levels when comparing patients with PCOS with controls, while non-obese PCOS patient's exhibit increased TG level, LH/ FSH ratio and free testosterone but lower FSH and E2 levels than matched controls. Moreover obese PCOS exhibit increased AP-36 level, copeptin, fasting insulin level and HOMA-IR than non-obese PCOS. AP-36 level and copeptin are positively correlated with BMI in patients with PCOS and are not directly implicated in the pathogenesis of PCOS, but might be involved as an adipokine that is affected by BMI.
Authors and Affiliations
Ahmed A Fadil Saedii, Amel M Kamal, Emad A AbdelNaeem, Ragaa A Matta
Keywords
Related Articles
- EP ID EP299196
- DOI 10.21767/2472-1093.100030
- Views 74
- Downloads 0
Changing Trends in Antibiogram and Molecular Analysis of Quinolone Resistant Salmonella typhi Isolates in Pakistan
Multidrug resistance is the ongoing burning issue in Salmonella typhi around the whole globe. This study was conducted to investigate changing trends in antibiotics resistance and mechanism of resistance against Nalidixi...
Telavancin Activity Against a Global Collection of Staphylococcus aureus Clinical Isolates (2013–2015)
Telavancin had MIC50, MIC90, and MIC100 values of 0.03, 0.06, and 0.12 μg/mL, respectively, against methicillinsusceptible (MSSA), methicillin-resistant (MRSA), and MRSA multidrug-resistant (MDR) subsets of Staphylococcu...
Antibiotic Susceptibility Pattern of Escherichia coli Isolated from Out-patient Individuals Attending the University College Hospital (UCH), Ibadan, Nigeria
A retrospective review of culture media of urine, ascitic fluid, sputum, tracheal aspirate, wound biopsy, antral washouts and blood was taken. The aim of this study was to determine the prevalence and antimicrobial susce...
Apelin-36 and Copeptin Levels in Polycystic Ovary Syndrome
he polycystic ovary syndrome PCOS is conventionally defined as a combination of hyperandrogenism and anovulation with polycystic ovaries. In many countries, it represents the leading cause of female infertility. The spec...
Antibiotic Use And Practices In Selected Fish Farms In The Ashanti Region Of Ghana
Background: Antibiotics may be used in fish farms to prevent or treat bacterial infections especially in hatcheries. This affects a wide range of bacteria and has potential impact on receiving water bodies and fish patho...