Association of DNA damage and dyslipidemia with polycystic ovarian syndrome
Journal Title: Journal of Medical and Allied Sciences - Year 2013, Vol 3, Issue 1
Abstract
Polycystic ovary syndrome (PCOS) is associated with hyperinsulinemia and insulin resistance which may lead to cardiovascular diseases. Evidence for cardiovascular events in women who were affected by PCOS during fertile age is limited. The pathogenesis is unknown; however, it is a complex multigenetic disorder. The present study was undertaken to evaluate the various cardiovascular risk factors and their DNA repair efficiency in women with PCOS by investigating the biochemical, endocrinological and molecular cytogenetic alterations. These investigations were carried out in 116 women in the age group of 15-35 years clinically diagnosed with PCOS. Data were compared with that of 50 agematched healthy normal women. Fasting blood sugar (FBS), Lipid profile, Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH), Prolactin and Estradiol were estimated after getting the informed consent. Mutagen induced chromosome sensitivity analysis was carried out in the lymphocytes of the subjects to assess the DNA repair proficiency. Fasting Blood Sugar, total cholesterol and LDL cholesterol were found to be elevated whereas HDL cholesterol was found to be lowered in the test subjects. FSH, LH and prolactin were also found to be significantly elevated in the test subjects. Change in the estradiol concentration in the test subjects was not significant. The mutagen sensitivity analysis revealed a significant elevation in break per cell (b/c) values indicating a deficiency in the DNA repair mechanism / DNA damage in PCOS patients. Modification of life style by changing the dietary habit and sedentary life style will help to reduce the oxidative stress and may increase the ovarian function and a sensible lifestyle management is recommended for reducing the risk for CVD.
Authors and Affiliations
Manikkumar R| Vinayaka Missions University, Salem-636308, Tamil Nadu, India, Dinesh Roy D| Genetika, Centre for Advanced Genetic Studies, Trivandrum-695024, Kerala, India, Viji Krishnan| Department of Biochemistry, PSGIMSR, Coimbatore-695024, Tamil Nadu, India, T Vijayakumar| Basic Medical Sciences, Educare Institute of Dental Sciences, Malappuram, Kerala- 676504, India
Keywords
Related Articles
- EP ID EP12680
- DOI -
- Views 378
- Downloads 23
Rifampicin-induced interstitial nephritis: A case report and a short review of the literature
Rifampicin induced acute interstitial nephritis (AIN) is a relatively rare entity, but in a setting of high tuberculosis (TB) prevalence, may be met with on occasion. TB is rife. If diagnosed and treated in time, the...
Lobular capillary hemangioma of esophagus mimicking Barrett’s esophagus
A 30 year old male patient presented to the outpatient department of Gastroenterology with complaints of dyspepsia of 6 months duration associated with progressive dysphagia to solids and liquids. There was no noticeab...
The use of insulin for early diagnosed patients with type 2 diabetes mellitus in primary health care in Indonesia: a general practitioner’s perspective
Indonesia, one of the greatest population countries, contributes a significant increase of global prevalence of type 2 diabetes mellitus. The need of insulin treatment is significantly rising as many cases do not meet...
Lumbar disc cyst with contralateral radiculopathy
Disc cysts are uncommon intraspinal cystic lesions located in the ventrolateral epidural space. They communicate with the nucleus pulposus of the intervertebral disc and cause symptoms by radicular compression. We repo...
Vaccinology: Reflections and the way forward
In recent times vaccine development exploration accelerates the new strategies based on genomics, proteomics, functional genomics and glycochemistry (synthetic chemistry). The evolving Advanced technologies have the pot...