Blood cadmium levels increase prostate specific antigen and insulin-like growth factor-1 among cadmium exposed workers

Journal Title: Universa Medicina - Year 2017, Vol 36, Issue 1

Abstract

BACKGROUND Cadmium (Cd) is a heavy metal that is classified as a human carcinogen (group IA), one of the cancers that it can cause being prostate cancer. The development of prostate cancer on a molecular basis involves oncogenes such as insuline-like growth factor-1 (IGF-1). Prostate cancer can be detected in the laboratory through the examination of prostate specific antigen (PSA). The present study aimed to determine the relationship of Cd levels with levels of PSA and IGF-1 in exposed and unexposed workers. METHODS The study design was cross sectional. The subjects of the studycame from two groups of workers, ie. the group of Cd exposed workers who were welding shop workers and the group of unexposed workers who were office workers. The minimum samplesize was 85 people. The independent variable was blood Cd level. The dependent variables were PSA and IGF-1 levels. Blood Cd levels were measured by atomic absorption spectrometry (AAS), while PSA and IGF-1 were measured using ELISA. Data analysis was performed using the Mann-Whitney test and the Spearman correlation test. RESULTS Mean blood Cd level in the exposed workers was 6.5 mg/L and in the unexposed workers 2.15 mg/L. There was a relationship between blood Cd and PSA levels (p<0.05) and between blood Cd levels and IGF-1 (p <0.05). CONCLUSIONS There was a relationship of blood Cd with PSA and IGF-1 levels.among workers. PSA and IGF-1 could be a biochemical markers of disease control in cadmium exposed workers.

Authors and Affiliations

Nendyah Roestijawati, Lintje Setyawati Maurits, Sugiyanto Sugiyanto

Keywords

Related Articles

Cervical consistency index is a valid predictor of preterm birth in low-risk pregnant women

Background Preterm birth (PTB) remains a global problem associated with perinatal morbidity, including low birth weight, growth retardation and irreversible damage to the nervous system. The objective of this study was t...

Combination of aerobic exercise and Hibiscus sabdariffa Linn. increased nitric oxide in rats

Background Hypertension and myocardial infarction account for the high rate of mortality globally. Hibiscus sabdariffa (HS) Linn. is rich in antioxidants and previous studies have demonstrated its anti-hypertensive effe...

Asiaticoside increases aquaporin-3 protein expression in the cytoplasm of normal human epidermal keratinocytes

Introduction Skin hydration decreases with aging. Aquaporin-3 (AQP3) is a major protein that plays a role in skin hydration, therefore it is a novel target for skin moisturizing treatment. Retinoic acid (RA) as a well-kn...

Membrane potential, serum calcium and serum selenium decrease in preeclampsia subjects in Owerri

Background Pre-eclampsia is a serious hypertensive condition of pregnancy associated with high maternal and fetal morbidity and mortality. Women who have had pre-eclampsia have a greater risk of developing hypertension,...

Decreased adiponectin level in adults with central obesity and low 25-hydroxy vitamin D level

Background Vitamin D insufficiency is associated with obesity and central obesity, which is in turn associated with the accumulation of visceral fat. Visceral fat secretes adiponectin which has a role in the pathogenesis...

Download PDF file
  • EP ID EP383185
  • DOI 10.18051/UnivMed.2017.v36.42-48
  • Views 141
  • Downloads 0

How To Cite

Nendyah Roestijawati, Lintje Setyawati Maurits, Sugiyanto Sugiyanto (2017). Blood cadmium levels increase prostate specific antigen and insulin-like growth factor-1 among cadmium exposed workers. Universa Medicina, 36(1), 42-48. https://europub.co.uk/articles/-A-383185