Clinical Experience of Rhino-orbito-cerebral Mucormycosis: Retrospective study of 18 cases
Journal Title: Medpulse International Journal of Ophthalmology - Year 2017, Vol 3, Issue 1
Abstract
Background: Rhino-orbital-cerebral mucormycosis (ROCM), acute and aggressive fungal infection, usually occurs in several immunocompromised states. Patients manifest with signs and symptoms relating to the involved tissues. Treatment includes control of metabolic abnormality, administration of amphotericin B and surgery. In this retrospective study we evaluated the clinical features and outcome of treatment of 18 cases of rhino-orbital and ROCM in relation to the early diagnosis and intervention and predisposing co-morbid systemic conditions. Material and Methods: In this retrospective study, 18 consecutive patients with a diagnosis of ROCM and ROM were reviewed. All were treated with Amphotericin-B and nine with ROM underwent surgical debridement in addition. All were followed up to 11 months and outcome was analyzed. Results: Sinusitis, pharyngitis, or nasal discharge (84.21%) was the most frequent presentation followed by orbital or periorbital pain (73.68%). Nine patients with RO diagnosis and treated with surgical debridement along with Amphotericin-B survived and all the nine patients with ROCM died. Conclusion: Patients who received surgical treatment in addition to amphotericin B had a better outcome than those who received amphotericin B alone. Uncontrolled diabetes mellitus was the most common risk factors. A high index of suspicion and improved laboratory diagnosis are important for improving the outcome of this devastating fungal infection.
Authors and Affiliations
Sakshi Ravikant Patil, Ajit K Joshi, Amit Pathak, Anil Kulkarni
Keywords
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- EP ID EP259905
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