Clinical profile and treatment response of primary Focal Segmental Glomerulosclerosis (FSGS) in Eastern Indian Children
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 4
Abstract
Currently, there is very little information about the spectrum of clinical profile and treatment response of children presenting with primary Focal Segmental Glomerulosclerosis in India and other South East Asian countries. This entity is an important component of childhood nephrotic syndrome because of its high chance of progression to Chronic Kidney Disease and End Stage Renal Disease. This retrospective study was conducted from June 2009-February 2014 to determine the spectrum and treatment response of primary Focal Segmental Glomerulosclerosis in children at a tertiary level hospital. All children aged between 6 months-14 years with biopsy proven Focal Segmental Glomerulosclerosis were included in the study. Their demographical, clinical and histopathological data were studied from case files. Treatment was given as per Indian Society of Paediatric Nephrology guidelines and responses that occurred were documented. Statistical analysis was done using Microsoft Excel software. We found that 31 (22.14%) children in our study had primary Focal Segmental Glomerulosclerosis with 64.51% being males. The mean age was 5.51 ± 3.82 years. Most of these cases had presented clinically with Steroid Resistant Nephrotic Syndrome (64.51%). Majority went into remission (90.3%) with immunosuppressive medications. Our results indicated that response to Cyclosporine-A is better compared to oral Cyclophosphamide (p= 0.00098). Hence, it maybe advocated in a paediatric patient with SRNS after renal histopathology primary Focal Segmental Glomerulosclerosis.
Authors and Affiliations
Pawan Mutalik
Keywords
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