Comparative effect of rosemary hydroalcoholic extract and selegiline on Parkinson's behavioral symptoms
Journal Title: Journal of Alternative Veterinary Medicine - Year 2020, Vol 3, Issue 7
Abstract
Background and aim: Parkinson's disease (PD) is a neurological disorder that is mainly associated with disruption of dopaminergic neurons in the substantia nigra. Seleglin acts as a neuroprotector to improve Parkinson's symptoms and slow the progression of the disease. Medicinal plants have been considered from ancient times to reduce the symptoms of Parkinson's disease; however, the effective doses of these drugs are not known. The aim of this study was to compare the effects of rosemary and Seleglin on behavioral symptoms of Parkinson’s animal model. Materials and methods: Sixty mature mice in the weight range of 25 to 30g were divided into seven groups: control, Parkinson’s, Seleglin, and 50,100, and 200 mg/kg of hydro-alcoholic extract of rosemary. In order to induce Parkinson's disease, rotenone poison was injected intraperitoneal in 1, 2, and 3 mg/kg doses every other day for 19 days. Control group received only rotenone carrier (dimethyl sulfoxide and sunflower oil) in 48 ml/kg dose. Rearing and bar behavioral models were used to evaluate the disease. Results: Hydro-alcoholic extract of rosemary in 200 mg/kg dose increased the duration of animal's presence on 10 cm bar significantly and the number of animal attempts in 20 cm glass cylinder which indicate reduction of Parkinson’s symptoms. Also, this dose increased movement activity of mice significantly. Conclusion: According to results, rosemary’s extracts can affect Parkinson’s symptoms dose dependently.
Authors and Affiliations
Nooshin Imani, Mehrdad Modaresi
Keywords
Related Articles
- EP ID EP698428
- DOI -
- Views 99
- Downloads 0
The effect of vitamin E and selenium on treatment process, serum malondialdehyde and vitamin D levels of cows with mastitis
Background and aim: The aim of this research was to investigate the effect of vitamin E and selenium on mastitis treatment outcome and Malondialdehyde (MDA) and vitamin D level in serum. Materials and methods: In this...
The effect of Trachyspermum optical aqueous extract on blood Homeostasis
T. capsicum from medicinal herbs is considered as a rich source of thymol with healing properties. Enzymatic coagulation factors stem from the liver. In the present study, 48 adult Wistar male rats were selected and divi...
The effect of seasons on the health and microbial contamination of creamy pastries in Isfahan
Food quality control after production is considered very essential for the consumers health. Among the foods, creamy pastries are much more important because of their high demand and consumption, high humidity and the po...
Radiographic study of navicular bone in hind feet of sound Dareh-shori horses
Navicular abnormalities has long been considered one of the most common causes of fore limb lameness. Radiographic evaluation is one of the most valuable, economic, and initial diagnostic tools used in the evaluation of...
Isolation and molecular Identification of Streptococcus mutans and evaluation of the antimicrobial effect of some herbal plant extracts on them
Introduction and aim: Overuse of antibiotics culminated in increasing of frequency of occurrence of antibiotic resistant bacteria. Therefore, new drugs with minimum complication are needed. Nowadays, herbal drugs as new...