Comparative study of clonidine and dexmedetomidine as adjuvants to bupivacaine in wound infiltration for postoperative analgesia after abdominal hysterectomy: A prospective randomized study
Journal Title: Medpulse International Journal of Anesthesiology - Year 2019, Vol 9, Issue 3
Abstract
Background: Wound infiltration with local anesthetics is a simple, effective and inexpensive means of providing good analgesia for a number of surgical procedures without any major side-effects. Aims: To compare the postoperative analgesic efficacy of clonidine and dexmedetomidine administered in wound infiltration with bupivacaine. Methods: Sixty women posted for abdominal hysterectomy belonging to American Society of Anaesthesiologists’ Grade 1or 2 were randomly allotted to following two groups: Group BC received wound infiltration with 30 ml 0.25% bupivacaine with 3µg/kg clonidine; Group BD received wound infiltration with 30 ml 0.25% bupivacaine with 1μg/kg dexmedetomidine. A standard general anaesthesia technique was used in all the patients. Postoperative pain score, duration of effective analgesia, number of patients requiring rescue analgesic and side effects were compared between the groups. Results: Post-operative pain score was comparable in the two groups (p>0.05). There were no significant differences between the groups in terms of duration of analgesia (p value 0.7422) and number of patients requiring rescue analgesia (p value 0.5731) and the level of sedation (p>0.05). Conclusions: 3µg/kg clonidine and 1µg/kg dexmedetomidine are comparable adjuvants to bupivacaine in wound infiltration for postoperative analgesia with equal efficacy and without any significant side effect.
Authors and Affiliations
Netravathi H, Anish Sharma NG, Bhavya v
Keywords
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- EP ID EP521623
- DOI 10.26611/10159323
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