Comparative study of dexmedetomidine and clonidine along with ropivacaine in epidural anaesthesia for vaginal hysterectomy
Journal Title: Medpulse International Journal of Anesthesiology - Year 2017, Vol 3, Issue 1
Abstract
Background: The present randomized double blind prospective study was carried out for Comparison of Dexmedetomidine and Clonidine along with Ropivacaine in epidural anaesthesia for vaginal hysterectomy. Methods: 60 female patients of ASA grade I and II, between the age group of 45 - 60 years were randomly assigned to 2 groups. Group RD: received 17 ml of 0.75% Ropivacaine Hcl and 1µg/kg of Dexmedetomidine Hcl, Group RC: received 17 ml of 0.75% Ropivacaine Hcl and 2µg/kg of Clonidine Hcl in supine position via epidural catheter. Onset, quality, duration of sensory and motor block and hemodynamic parameters evaluated. Results: Patients from Group RD have fast sensory block onset (i.e. 9.96±0.61min), prolonged two seg. regression time (138.93±4.48) and prolonged Analgesia time ((i.e 353.9±4.03min) as compared to Group RC i.e. (12.4±0.77), (128.8±3.46),(308.06±5.47) respectively. The duration of motor blockade was prolonged in patients of group RD (242.23±5.72min) as compared to the patients in group RC (230.66±5.20min). Patients in group RD were more sedated as compared to the patients in group RC. Initial fall in heart rate was more in patients of RD group as compared to the patients of group RC but later on both the groups showed stable heart rate. Fall in systolic, diastolic and mean arterial blood pressure was more in patients of RD group (during 5 to 50- 55 min of epidural injection) as compared to the patients of group RC. Later on both the groups showed stable systolic blood pressure. Conclusion: Dexmedetomidine is better adjuvant as compared to Clonidine for providing early onset and prolonged intraoperative as well as postoperative analgesia, better sedative property Both the drugs showed bradycardia and hypotension which was clinically insignificant.
Authors and Affiliations
Jadhav Shashikant Abhimanyu, Kore Rahul Dharma
Keywords
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