Comparison of Efficacy of Intravitreal Aflibercept and Ranibizumab in Treatment-naive Diabetic Macular Edema
Journal Title: European Archives of Medical Research - Year 2019, Vol 35, Issue 3
Abstract
Objective: The purpose of this study was to compare the efficacy of two different intravitreal anti-vascular endothelial growth factor (anti-VEGF) agents in two treatment-naive and statistically equal cohorts of diabetic macular edema patients. Methods: In this retrospective study, 81 eyes of 64 treatment-naive diabetic macular edema (DME) patients were enrolled. Patients were divided into two groups and both groups were treated [37 eyes with intravitreal 0.5 mg ranibizumab (IVR) and 44 eyes with intravitreal 2 mg aflibercept (IVA)] with three consecutive injections at intervals of one month. All patients underwent a detailed eye examination including optic coherence tomography and best corrected visual acuity (BCVA; Snellen), biomicroscopy, fundoscopy and applanation tonometry at preoperative, 1st, 2nd and 3rd month. BCVA values were converted into logarithm of the minimum angle of resolution (logMAR) for statistical analyses. Data were evaluated with SPSS 25.0. Results: Mean BCVA (logMAR) increased from 0.58±0.28 to 0.43±0.29, 0.39±0.25 and 0.32±0.26 (p=0.001, p<0.001, p<0.001) in the IVR group and from 0.54±0.28 to 0.41±0.34, 0.43±0.39 and to 0.32±0.37 (p=0.004, p=0.023, p<0.001) in the IVA group. Mean central macular thickness (CMT) decreased from 406±82 μm to 345±65 μm (1st month), 332±83 μm (2nd month) and finally to 303±60 μm (3rd month) (p<0.001) in the IVR group and from 415±88 μm to 328±79 μm, 297±54 μm and finally to 277±54 μm (p<0.001) in the IVA group, respectively. There was no significant difference between the groups in terms of BCVA (p>0.05). In the subgroup analysis, CMT gain in patients with moderate DME (CMT ≤385 μm) was found significantly better in the IVA group compared to the IVR group (1st month: 36.9 vs. 83.6, 2nd month: 36.2 vs. 106.3, 3rd month: 3nd 72.7 vs. 125.1; p<0.05). Conclusion: Both anti-VEGFs were equally effective in visual outcomes. Compared to ranibizumab, aflibercept has a rapid and superior therapeutic effect in anatomical results, especially in moderate DME cases.
Authors and Affiliations
Burak Erden, Akın Çakır, Selim Bölükbaşı, Ali Cihat Aslan, Mustafa Nuri Elçioğlu
Keywords
Related Articles
- EP ID EP549065
- DOI 10.4274/eamr.galenos.2019.72792
- Views 180
- Downloads 0
Isolated Finding of Intermittent Compression of the Trochlear Nerve by a Dolichoectatic Basilar Artery
Vertebrobasilar dolichoectasia (VBD) is a rare disorder characterized by elongation and tortuosity of the vertebrobasilar arteries. Clinical manifestations can range from ischemic stroke and progressive compression of cr...
Comparison of Wide Awake Local Anaesthesia No Tourniquet Technique with Tourniquet Application under General Anesthesia in Carpal Tunnel Syndrome: A Retrospective Study
Objective: Carpal tunnel syndrome is a common complaint in orthopedic practice and usually treated with surgical intervention. The aim of the study was to compare wide awake local anesthesia no tourniquet (WALANT) techni...
New Developments in Oncological Treatment: Targeted Treatments and Immunotherapy
In the last 20 years, when we started to understand cancer biology better, targeted therapies and immunotherapies have been developed in systemic treatments and they have started to take their place as monotherapy or com...
Comparison of Bipolar TURP and Monopolar TURP Patients Who Underwent Surgery Due to Benign Prostatic Hyperplasia
Objective: Benign prostatic hyperplasia (BPH) is the one of the most common disease in the world. Transurethral resection of prostate (TURP) is the gold standard procedure in BPH surgery. So TURP methods are important. T...
Evaluation of Echocardiographic Findings of Mucopolysaccharidosis Cases
Objective: Mucopolysaccharidosis (MPS) is a lysosomal storage disease in which the degradation of glycosaminoglycans is impaired. Cardiac involvement may occur in different ways in all types of the disease. In this study...