COMPARISON OF ERYTHROPOIETIN AND DARBEPOETIN IN CHRONIC KIDNEY DISEASE PATIENTS IN A TERTIARY CARE HOSPITAL
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2017, Vol 5, Issue 1
Abstract
Chronic kidney disease (CKD), is a progressive loss of kidney function over several months to years and cause complications like anaemia. Erythropoiesis stimulating agents (ESAs) such as erythropoietin and darbepoetin are widely used as a first-line treatment for the management of renal anaemia in CKD patients . Treatment of anaemia with ESAs could reduce the need for red blood cell transfusion and improve outcome and quality of life (QOL).As there are not enough studies in Indian literature regarding the comparison of erythropoietin and darbepoetin in chronic kidney disease patients, the present review is undertaken. This review is designed to compare the effect of erythropoietin and darbepoetin by measuring serum Haemoglobin and creatinine in CKD patients .In review articles it is observed that erythropoietin and darbapoetin shows comparable effect in bringing Hb to normal ranges but there observe an increase in creatinine in some patients. Darbepoetin is a unique erythropoietic agent with an approximately threefold longer half-life than erythropoietin, allowing less frequent dosing than erythropoietin.
Authors and Affiliations
Mathew George| Department of Pharmacology, Pushpagiri College of Pharmacy, Thiruvalla-689107, Kerala, India., Lincy Joseph| Department of Pharmaceutical Chemistry, Pushpagiri College of Pharmacy, Thiruvalla-689107, Kerala, India., Christy K Jose| Department of Pharmaceutical Chemistry, Pushpagiri College of Pharmacy, Thiruvalla-689107, Kerala, India., Pournami A S*| Department of Pharmaceutical Chemistry, Pushpagiri College of Pharmacy, Thiruvalla-689107, Kerala, India.
PHYTOCHEMICAL AND ANTIMICROBIAL INVESTIGATION OF NYMPHAEA NAUCHALI LEAF NATIONAL FLOWER OF BANGLADESH
The methanolic extracts of Nymphaea nauchali was evaluated for antimicrobial activity against clinically significant bacteria Staphylococcus aureus, Pseudomonas aureus, Pseudomonas aeruginosa, Bacillus subtilis, Bacilliu...
FORMULATION AND OPTIMIZATION OF ONDANSETRON HYDROCHLORIDE ORODISPERSIBLE TABLETS
The demand for mouth dissolving tablets has been growing, during the last decade especially for geriatric and pediatric patients because of swallowing difficulties. Orodispersible tablets of Ondansetron hydrochloride wer...
Formulation Development and evaluation of ibuprofen sustained release matrix tablet using Lepidium Sativum mucilage
Ibuprofen is one of the safest and most potent non-steroidal anti-inflammatory drugs (NSAID) available in the market. The objective of present study was to prepare and evaluate sustained release matrix tablets of ibuprof...
Navaneeta-kalpa-A Novel approach
Rasashastra the treasure of scientific solution to mankind diseases explains various specific mineral, herbomineral preparations. Navaneeta kalpas (Preparations made up of butter as one of the ingredient) are being spec...
Pharmacological evaluation of 2-chloro substituted thiophene compound for antiinflammatory activity in rats
Introduction: Inflammation is a phenomenon associated with almost every disease process. It has always been a challenge to halt the inflammatory process with various drugs and to identify a drug with least side effects....