Concomitant Use Of Policosanol And Diuretics In Older Patients With Type Ii Hypercholesterolemia
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2018, Vol 8, Issue 9
Abstract
Objective: The objective of the present analysis as a part of a Prevention Study, we investigated whether concomitant administration of policosanol with diuretics induces some specific adverse event or disturbance on any safety indicator in older patients. Methods: We randomised 1470 elderly patients at high coronary risk to policosanol 5 mg/day or placebo for 3 years. For this analysis, the records of all patients (368) taking diuretics were included. Analysis was by Intention-to-treat. Results: Both groups were well matched at baseline. Policosanol effects persisted during the whole study. At study completion, policosanol reduced low-density lipoprotein cholesterol (LDL-C) (29.1 %), total cholesterol (19.6 %), triglycerides (22.5 %) and raised high-density lipoprotein cholesterol (HDL-C) (13.8 %). Of 368 patients consuming diuretics, 76 (20.7 %) discontinued the study, 49/181 placebo (27.1 %) and 27/187 policosanol (14.4 %) patiens. Of them, 37 patients (25 placebo, 12 policosanol) discontinued prematurely the study because of some adverse event. No disturbance of any safety indicator was found. Diastolic and systolic blood pressures, however, was lowered in policosanol group compared with placebo. The extent of serious adverse events, most vascular, in policosanol patients (9/187, 4.8 %) taking diuretics was lesser than in placebo (23/181, 12.7 %). Policosanol did not increase the frequency of mild and moderate adverse events compared with placebo.Conclusion: It is concluded that policosanol therapy added to older hypercholesterolemic patients taking diuretics produced relevant benefits on lipid profile, blood pressure and the frequency of serious adverse events respect to placebo, then indicated concomitant with diuretic in elderly, without increase any adverse event.
Authors and Affiliations
José Illnait- Ferrer, Julio César Fernández- Travieso, Lilia Fernández- Dorta, Sarahí Mendoza- Castaño, Rosa Más- Ferreiro, Rafael Gámez- Menéndez, Ernesto López- González, Meilis Mesa- Angarica
Keywords
Related Articles
- EP ID EP402077
- DOI -
- Views 88
- Downloads 0
Analysis of used disinfectants and antiseptics correlated with the occurrence of nosocomial infections – Clinical hospital Stip, Republic of Macedonia in period of 2007 – 2011
: Intra-hospital or nosocomial hospital infections are caused by microorganisms acquired during the hospitalization of the patient, and clinically are manifested from 48 to 72 hours after admission at earliest.The...
A Cognitive Capabilities and Gender Differences in Transition Period: A Study Of Lucknow City
The potential effect of gender on intellectual abilities remain controversial. A variety of research has been conducted on A Cognitive Capabilities and Gender Differences in transition period Objective: To assess...
Cardiotonic activity of Parotoid gland secretion of common Indian Toad Bufo melanostictus on isolated heart of Frog
:The present investigation has been undertaken to study the cardiotonic activity of parotoid gland secretion of common Indian Toad Bufo melanostictus on isolated perfused frog heart (Rana tigrina). Cardiotonic...
Splenic Abscess: Etiology, clinical spectrum and Therapy
ABSTRACT: Spleen abscess is a rare entity, only 600 cases reported in the literature, it has a high mortality in immunocompromised patients, and delay in diagnosis and treatment. Splenic abscess is more common in patien...
Dynamics of Combined Oral Contraceptive: A Study of Some Cytokines in Female Wistar Rats
Oral contraceptives are a simple form of contraception used by women worldwide. The oral contraceptive is one of the greatest and most influential developments of the twentieth century. It is regarded as the...