CYCLODEXTRIN A GIFT TO PHARMACEUTICAL WORLD REVIEW
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 1
Abstract
The macrocyclic cyclodextrins (enzymatic conversion products of starch) were discovered in 1891, and the structures were elucidated in the mid-1930s. Their industrial significance become obvious in the 1970s, and by now thousands of tons of the three cyclodextrins (α-, β-, and γCD) and of their chemical derivatives and inclusion complexes are produced industrially. The paper highlights important CD applications in drug solubility and dissolution, bioavailability, safety, and stability, their use as excipients in drug formulation, design of various novel delivery systems like liposome, microspheres, microcapsules, and nanoparticles. Recently Thorsteinn et. al. filled a patent on nano ophthalmic composition which is an aqueous suspension comprising drug, cyclodextrin and water1. The size of the solid particles being from about 10 nm to about 1 mm, the drug/cyclodextrin particles being capable of dissolving in aqueous tear fluid within 24 hours of application to the eye surface. Eunsook Cho et.al used sulfobutylether ß-cyclodextrin in formulation of nasal drug delivery of ondansetron HCl. The addition of 10% SBCD to aqueous solution containing 10% PEG 300 and 0.01% Benalkonium chloride could be a good candidate for ondansetron nasal delivery systems because of its safety profile, stable storage in refrigerator and solubilizing effect. The article also focuses on various factors influencing inclusion complex formation because an understanding of the same is necessary for proper handling of these versatile materials. Some important considerations in selecting CDs in drug formulation such as their commercial availability, regulatory status, and patent status are also summarized. Apart from these various properties of different cyclodextrin are also discuss in these paper.
Authors and Affiliations
Akshay Katageri , Mohsin Sheikh
Keywords
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