DETERMINATION OF COVERAGE INTERVAL OF MICROPROTEIN IN URINE IN PREGNANT LADIES BY THE PYROGALLOL-RED METHOD IN PATIENTS ATTENDING A TERTIARY CARE HOSPITAL IN EASTERN INDIA
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 91
Abstract
BACKGROUND Pre-eclampsia characterised by hypertension and proteinuria in pregnancy is a major cause of maternal morbidity worldwide. So it is important to quantify the protein excretion in urine during pregnancy to help clinicians to predict pre-eclampsia in vulnerable patients. Traditionally, the estimation of 24 hours protein excretion in urine has been used for this purpose which is a cumbersome process. The dipstick method, though an easier one, does not yield satisfactory results. The pyrogallol-red method is perhaps a more acceptable method in this regard. It has also been noted that there exists almost no relevant data on pregnancy proteinuria in this part of the country. In light of this background, we embarked on this study to determine the coverage interval of microprotein in urine by the pyrogallol-red method in pregnant patients attending a tertiary care hospital in Eastern India. MATERIALS AND METHODS This cross-sectional study was carried out on 71 pregnant ladies attending the antenatal clinic in the Gynaecology and Obstetrics Department at College of Medicine and Sagore Dutta Hospital, a tertiary care hospital in Kolkata. The protein in fresh, clean voided urine of pregnant patients was estimated by the pyrogallol-red method on ERBA Chem 5x semi-auto analyser. The statistical data thus obtained was analysed by IBM SPSS version 16. RESULTS It may not be always feasible to collect 120 samples to establish a reference interval as required by the IFCC. For this reason, the term coverage interval is preferred over reference interval by IUPAC. The coverage interval of pregnancy proteinuria was calculated to be 23.99—29.64 mg/dL with a confidence of 0.90 and uncertainty of 0.049. CONCLUSION In this study, we conclude that the coverage interval of urinary microprotein for pregnancy proteinuria is 23.99—29.64 mg/dL as determined by the pyrogallol-red method.
Authors and Affiliations
Purvita Dam, Sharmistha Chatterjee, Sanjoy Kunti, Indranil Chakraborty, Sanghamitra Chakraborty
Keywords
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- EP ID EP278285
- DOI 10.14260/jemds/2017/1390
- Views 72
- Downloads 0
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