DEVELOPMENT AND IN VITRO EVALUATION OF FILM COATED MICRONIZED IMMEDIATE RELEASE TABLETS OF URSODEOXYCHOLIC ACID
Journal Title: International Journal of Pharmaceutical Science and Technology - Year 2010, Vol 5, Issue 2
Abstract
Ursodeoxycholic acid (UDCA) belongs to Biopharmaceutical Classification System (BCS) class II and hence it exhibits low aqueous solubility and high permeability. Solubility of this drug is very low which affects in low dissolution rate and in turn affect the bioavailability of this drug following oral administration. The micronization of drug is one of the promising ways to improve the bioavailability of poorly watersoluble compounds due to increased dissolution rate. The purpose of the present study is to design an immediate release tablet containing ursodeoxycholic acid and to compare the drug dissolution profile with the tablets containing micronized drug. A significant increase of in vitro drug release rate is observed in case of the micronized product over the non micronized one.
Authors and Affiliations
Jayanti Mukherjee , Bappaditya Chatterjee , Utpal Nandi , Sanmoy Karmakar , Tapan Kr Pal
Keywords
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- EP ID EP103371
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