Effect of Progesterone Supplementation to Prevent Preterm Labor
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 4
Abstract
Preterm birth is the most important problem in maternal and child health throughout the world. It complicates one in eight deliveries and accounts for over 85% of all perinatal morbidity and mortality. On February 3, 2011, the US food and drug administration (FDA) approved the use of progesterone supplementation during pregnancy to reduce the risk of recurrent preterm birth in women without prior spontaneous preterm delivery. Aim 1. To determine the impact of progesterone therapy in prevention of preterm labor. 2. To measure the maternal and perinatal outcome in those treated by progesterone. Materials and Methods Study Design: Randomized control trial Study Setting: Department of Obstetrics and Gynaecology, Government medical College, Kottayam, Kerala, India Study Period: March 2012 to March 2014 Methodology: 88 antenatal women with a previous history of spontaneous preterm vaginal delivery were chosen for the study and they were randomly assigned as cases who received progesterone and controls who do not receive progesterone. Natural micronized progesterone is used in this study. There is functional progesterone withdrawal which is a cause for onset and establishment of labor in both preterm and term deliveries. This is the rationale for providing progesterone to prevent preterm labor. Results: Progesterone is effective in preventing preterm labor in those women with a history of spontaneous preterm labor. Conclusion: Progesterone supplementation is a very good method to prevent preterm labor and should be continued until 37 weeks. There is significant improvement in neonatal outcome in progesterone users
Authors and Affiliations
Dr Cicily T J
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