Effective of Red Ginseng Extract on Ameliorate Adipogenesis 3t3-L1 by Decreasing P38 and Erk Phosphorylation
Journal Title: Journal of Diabetes and Obesity - Year 2016, Vol 4, Issue 1
Abstract
This study examined the anti-obesity effect and mechanism of action of red ginseng extract (RG) in 3T3-L1 cells. To measure the levels of lipid accumulation, we were observed of expression of genes and proteins, which is associated with adipocyte differentiation in 3T3-L1 cells. Eight days following induction for differentiation with MDI-medium and simultaneously with the tested RG, our study found significantly reduced (p < 0.05) intracellular triacylglycerol accumulations of 3T3-L1 cells by does dependent manner. RG decrease adipogenic markers, C/EBPα, C/EBPβ and PPARγ, which is a key regulator of adipocyte differentiation. In this study showed that C/EBPβ is regulated RG decreased the phosphorylations of p38 mitogen-activated protein kinase (MAPK) and extracellular signal–regulated kinases (ERK). These results suggest that the anti-adipogenic effect of RG in 3T3-L1 pro-adipocyte could be associated with the inhibition of adipogenic transcription factors by regulations with p38 MAPK and ERK phosphorylation.
Authors and Affiliations
Gi-Beum Kim
Keywords
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- EP ID EP417850
- DOI 10.15436/2376-0494.17.1233
- Views 119
- Downloads 0
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