Effects of mesenchymal stem cells to prevent adhesions for vascular reoperations: An experimental study
Journal Title: Damar Cerrahi Dergisi - Year 2019, Vol 28, Issue 3
Abstract
Objectives: In the present study, we aimed to investigate whether mesenchymal stem cells (MSCs) were useful to reduce cutaneous adhesions, particularly for vascular reoperations. Materials and methods: In this experimental study, 12 adult male Wistar Albino rats were used. In Group 1 (n=2, negative control group), no incision was performed. In Group 2 (n=5, positive control group), skin and subcutaneous tissues were incised. In Group 3 (n=5, MSC group), skin and subcutaneous tissues were incised and 3×106 MSCs were applied. Macroscopic scoring of adhesion and histopathological scoring of tissue repair response were evaluated. Results: Macroscopic view of the adhesion values (Padjusted <0.0175), histopathological evaluation values (histiocytic response, vascularization, and granulocytic response and total response) (Padjusted <0.0175), and collagen deposit values (Padjusted <0.0175) of Group 3 were significantly lower than Group 2. Conclusion: Our study results suggest that the use of MSCs seems to be useful to prevent adhesion formation in cutaneous injuries and that MSCs promote wound healing without adhesions in the experimental setting.
Authors and Affiliations
Mehmet Kabalcı
Keywords
Related Articles
- EP ID EP663544
- DOI 10.9739/tjvs.2019.560
- Views 70
- Downloads 0
Our surgical experiences on vascular injuries in Afrin Olive Branch operation
Objectives: In this study, we present our surgical experiences on vascular injuries during the Afrin Olive Branch operation of Turkey. Patients and methods: Between February 2018 and May 2018, a total of 37 traumatized p...
Long-term outcomes of unilateral iliac stenting and femorofemoral crossover bypass for bilateral extensive iliac disease
In recent years, hybrid procedures are routinely used in high-risk patients with severe aortoiliac occlusive disease. However, little is known regarding their long-term results, particularly in developing countries. Here...
The prevalence of arterial and venous abnormalities in asymptomatic patients undergoing total knee arthroplasty
Objectives: This study aims to investigate the prevalence of venous and arterial diseases in asymptomatic patients undergoing total knee arthroplasty (TKA) and to evaluate possible surgery-related vascular complications....
Surgical treatment of iatrogenic pseudoaneurysms
Objectives: This study aims to present the results of surgical treatment of femoral and brachial artery pseudoaneurysms after cardiac catheterization. Patients and methods: This retrospective study included a total of 28...
A novel technique in varicose vein surgery: Grasp-all-first
Many surgeons remove the varicose veins one by one. However, this technique is time-consuming with considerable blood loss, particularly in severely affected limbs. In advanced cases, varicose veins have a continuous str...