EVALUATION OF ANTIDIARRHOEAL ACTIVITY OF SIDA RHOMBIFOLIA LINN. ROOT
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 9
Abstract
The roots of Sida rhombifolia are used in traditional medicine for the treatment of diarrhoea. Thus the methanolic extract of Sida rhombifolia (Malvaceae) root was investigated for its antidiarrhoeal property to substantiate folkloric claim. The methanolic extract of Sida rhombifolia, at graded dose (200 and 400 mg/kg body weight) was investigated for antidiarrhoeal activity in castor oil induced diarrhoea. Results were comparable to that of standard drug Diphenoxylate (50mg/kg body weight). A single oral dose of Sida rhombifolia extract of 400 mg/kg body weight produced a significant decrease in the severity of diarrhoea. To understand the mechanism of its antidiarrhoeal activity, its effect was further evaluated on intestinal transit and castor oil induced intestinal fluid accumulation (enteropooling). Extract produced profound decrease in intestinal transit (57.73-61.84%) and significantly inhibited castor oil induced enteropooling comparable to that of intraperitonial injection of standard drug atropine sulphate. The results showed that the methanolic extract of Sida rhombifolia have a significant antidiarrhoeal activity and supports its traditional uses in herbal medicine.
Authors and Affiliations
Rashmi Sarangi , Uma Mishra , Susanta Panda , Saiprasanna Behera
Keywords
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