EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF HYDROETHANOLIC EXTRACT OF WHOLE PLANT OF CLEMATIS BUCHANANIANA DC AGAINST PARACETAMOL INDUCED LIVER INJURY IN WISTAR ALBINO RATS.
Journal Title: IJAR-Indian Journal of Applied Research - Year 2018, Vol 8, Issue 10
Abstract
Objective: To investigate the hepatoprotective activity of hydroethanolic extract of whole plant of Clematis buchananiana against Paracetamol-induced liver injury in wistar albino rats. Belong to family Ranuculaceae. The degree of protection was measured by estimation of serum biochemical parameters, histopathology study. Method: The albino wistar rats (120-180gm) were divided into 6 group 5 animals in each, Group I: Received distilled water (5ml/kg. p.o) once daily, and served as normal control. Group II: Received paracetamol suspension (640 mg/kg suspended in 1% methyl cellulose; orally as toxin control. Group III: Received standard drug Silymarin (25 mg/kg. p.o.) + paracetamol suspension (640 mg/kg suspended in 1% methyl cellulose; orally once daily Group IV, V, VI administered HEECB at different doses300, 400, 500 mg/kg orally + paracetamol suspension (640 mg/kg suspended in 1% methyl cellulose; for 21 days. And collect blood from experimental animals by retrorbital puncture for estimation of biochemical parameters and other parameter also evaluate like physical histological changes in livers of rats. Results: Experimental finding reveal that Paracetamol produce significant change in physical (increase liver weight) biochemical (increase alkaline phosphate, serum glutamic oxalacetic transaminase, serum glutamic pyuruvic transaminase, total protein, total bilirubin, direct bilirubin and decrease the level of total protein and albumin) histological (damage to hepatocyte) and in liver parameters. Pretreatment with extract significantly minimization of physical, biochemical, histological and functional change induced by Paracetamol in liver. Conclusion: Experimental data and analysis of different parameter declare that hydroethanolic extract of Clematis buchananiana could be a useful hepatoprotective agent and it has significant hepatoprotection potential it is possible due to their active constituent alkaloids. However further study still needed to be causes on exposure of extract to human beings.
Authors and Affiliations
Anita Singh, Manoj Bisht
Keywords
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