Evaluation of molecular tests in diagnosis of osteoarticular tuberculosis
Journal Title: International Journal of Orthopaedics Sciences - Year 2018, Vol 4, Issue 2
Abstract
Osteoarticular tuberculosis is a relatively uncommon type of extrapulmonary tuberculosis. It is an important cause of mortality and morbidity and accounts for approximately 10-15% of all extrapulmonary forms of tuberculosis. The diagnosis is difficult and hence often late. The disability resulting from osteoarticular tuberculosis is directly related to the time of detection of disease and initiation of treatment. A prospective study of 36 patients suspected with osteoarticular tuberculosis was done from August 2010 to December 2012 was done at St. stephens hospital Delhi. For the purpose of this study, a diagnosis of osteoarticular TB was based on a combination of suggestive clinical features, in conjunction with typical radiological findings associated with osteoarticular TB. The specimens were subjected to ZN staining, Real Time PCR, Bac-T alert culture & Accuprobe. The sensitivity of real time PCR was 100%, specificity was 58.8%, positive predictive value was 73%, negative predictive value was 100%, efficiency was 80.5% considering culture as gold standard. As shown by the study, each diagnostic test including Real time PCR has its own disadvantages and shortcomings and does not provide 100% accuracy in diagnosing osteoarticular tuberculosis, therefore, strong clinical suspicion and correlation along with radiological and laboratory evidence is a must in establishing a diagnosis.
Authors and Affiliations
Dr. Siddharth Lamba, Dr. Mrinal Mathur, Dr. Indira Sarin
Keywords
Related Articles
- EP ID EP486813
- DOI 10.22271/ortho.2018.v4.i2h.78
- Views 117
- Downloads 0
Functional outcome in patients with distal radius fractures treated with fragment specific fixation at tertiary care teaching hospital
Introduction: Aim of this study was to study the functional outcome in patients with distal radius fractures treated with ORIF with 2.7mm distal radius plates at 6 months using PRWE score. To study how early the patients...
Long term outcome analysis of fixed bearing total knee arthroplasty
Introduction: Survivorship of TKA is directly related to appropriate alignment and balance. Surgeons should evaluate the biomechanics of knee alignment and determine the proper position of the implant. Malalignment of to...
Management of idiopathic clubfoot by Ponseti’s technique
Background and objective: Idiopathic Congenital Talipes Equinovarus (CTEV) is a complex deformity that is difficult to correct. The treatment of clubfoot is controversial and continues to be one of the biggest challenges...
A prospective study to analyze the outcome of surgical stabilization of fractures of lower end of radius with Ellis plate
Introduction: The most common cause of distal radius fracture is a fall on an outstretched hand. Osteoporosis can make a relatively trivial fall result in a broken wrist. Many distal radius fractures in people older than...
Outcomes of local injections of platelet rich plasma in various chronic tendinopathies
Introduction: Tendinopathy is a repetitive strain injury caused by repetitive overuse of the muscles of the body. It causes pain and functional impairment in daily activities. The treatment of this condition includes con...