Expressions of CD36: Predictor marker of the early Kidney Injury in Type 2 Diabetic Mellitus
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 3
Abstract
Background: Patients with uncontrolled diabetes prone to end stage renal disease, require kidney transplantation, haemodialysis or peritoneal dialysis which adds psychological distress. Early prediction of kidney injury by evaluating expressions of CD36, a trans-membrane protein of the class B scavenger receptor family, in type 2 diabetic mellitus minimizes the risk of diabetic nephropathy. Methods:This study includes 241 subjects (118 male, 123 women, and age ranges 30-70 years) were included after screening for type 2 diabetic mellitusas per International Diabetic Federation guidelines. Subjects were groupedinto two groups after written consent and enrolled as per inclusion/exclusion criteria. Equal numbers of healthy volunteers enrolled in control group. Blood samples were processed for other renal parameters & rt -PCR to check expressions of CD36. Results: In study groups all renal and lipidparameters found withinnormal range except albumin/creatinine ratio (p >.012), e-GFR (p >.00) and total cholesterol (p >.00). Descriptive analysis showed that genetic expressions of CD36 found highly significant (p >.00) in microalbuminuria subjects Conclusion: Renal biochemical parameters are not enough to prevent diabetic nephropathy even in microalbuminuria due to its interpretive limitations. Early detection of gene expressions of CD36 may predict risk of kidney injury. Early management of disease progression may prevent morbidity & mortality of kidney due to diabetic nephropathy.
Authors and Affiliations
Khot VV, Yadav KS, Patil SB
Keywords
Related Articles
- EP ID EP592485
- DOI 10.9790/0853-160301113117
- Views 66
- Downloads 0
Randomised controlled trial comparing efficacy of two different doses of Intrathecal 0.75% Isobaric Ropivacaine in Elective Inguinal hernia surgery
INDRODUCTION :Ropivacaine was approved for a new route of administration, the intrathecal route, in the European Union in February 20041 . Ropivacaine was introduced into clinical practice in 1996, and has consistently d...
Surgical Management of Proximal Humerus Fractures – Assessment of Results
Background: Proximal humeral fracture whether caused by trauma or related to osteoporosis, requires carefully planned individual treatment. The choice of technique and devices depends on quality of bone, soft tissue, age...
“Determination of potential virulence factors in clinical isolates of various Candida species to assess its clinical implication in a tertiary care hospital in Eastern India”.
Candidiasis is the commonest fungal disease in human caused by various species of the yeast like fungi belonging to the genus Candida. It is commonly encountered as an endogenous infection due to its commensal nature. Tr...
Determination of malondialdehyde, Uric Acid, Bilirubin And Total Antioxidant Status, in Children Under 5 Years Suffering From Malaria in Osogbo, Nigeria
Background: Children are prone to malaria infection. Peroxidation of membranes lipids, hemolysis and oxidative stress due to invasion of erythrocytes by malaria parasites could worsen the disease and increase mortality....
A Comparative Study on Safety, Efficacy, and Cost of Glipizide versus Glimepiride as an Add-On Therapy to Metformin
Background: Diabetes Mellitus (DM) is associated with abnormalities in carbohydrate, fat, and protein metabolism. Pharmacoeconomic studies are pertinent to the decision-making process when trying to balance the costs of...