Formulation and Assesment of Clomifene Citrate Tablet by Direct Compression Method
Journal Title: RADS Journal of Pharmacy and Pharmaceutical Sciences - Year 2017, Vol 5, Issue 4
Abstract
The problem of Infertility is developing in western societies and also in eastern societies, some researches have examined the utilization of drug for widespread treatments of infertility. Clomifene citrate is the first-line management intended for normogonadotropic females with absent or asymmetrical ovulation. The objective of this study was to manufacture and analyze the clomifene citrate50 mg tablet by direct compression method. The manufacturing formula contain the material Clomifene citrate, lactose anhydrous, Silicon dioxide, MCC ph 102, Cross Carmellose Sodium, Primogel, Talcum, PVK-30 and Magnesium Stearate . After mixing these active and inactive ingredients, tablets were manufactured by direct compression method. We evaluated the formulation by pharmacopeial and non pharmacopeial methods such as hardness,thickness, friability, disintegration test, weight variation test, content uniformity and assay. The results were found satisfactory. The individual weights, average weights, thickness, disintegration tablets met the limits specified in BP and USP. Hardness, friability, assay and content uniformity also met the specified limits.
Authors and Affiliations
Fatima Qamar
Keywords
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