FORMULATION AND EVALUATION OF BUCCOADHESIVE GEL FOR THE TREATMENT OF ORAL SUBMUCOSAL FIBROSIS
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2014, Vol 2, Issue 6
Abstract
Oral submucosal fibrosis (OSF) is a disease affecting the oral cavity and characterized by chronic, complex, irreversible, potentially malignant disorder (PMD) and crippling condition of oral mucosa, various delivery systems for administration & delivery of drugs to the oral cavity for treatment of OSF have been developed. The developed delivery systems mostly contain a single drug, while treatment of OSF is based on multiple drug approach. In the present work it is proposed to formulate and evaluate buccoadhesive gel of two drugs that is metronidazole and lycopene as topical antioxidant. In the present study five batches of metronidazole and lycopene gels were prepared using natural biodegradable polymer Carbopol 934p and sodium carboxy methyl cellulose. The influence of polymer type and polymers blend in varying ratio on the viscosity, buccoadhesive strength, spreadability, extrudability and drug release were evaluated. SCMC based gel showed fastest release in comparison with Carbopol based gel. Using polymer blend of SCMC with Carbopol resulted in a modification of both release and physical properties. The release of metronidazole was decreased with increasing amount of Carbopol and decreasing amount of SCMC. And increasing the viscosity of the gel formulations resulted in a retardation effect on the release of the drug. The study also showed that formulas containing Carbopol exhibited maximum viscosity with lower release rates and best buccoadhesion.
Authors and Affiliations
Poonam Kumari*| Department of Pharmaceutics, Lachoo Memorial College of Science and Tech, Pharmacy Wing, Sector-A, Shastri Nagar, Jodhpur, Rajasthan-342003, India., Surender Singh Sourabh| Department of Pharmaceutics, Lachoo Memorial College of Science and Tech, Pharmacy Wing, Sector-A, Shastri Nagar, Jodhpur, Rajasthan-342003, India., Roshan Issarani| Department of Pharmaceutics, Lachoo Memorial College of Science and Tech, Pharmacy Wing, Sector-A, Shastri Nagar, Jodhpur, Rajasthan-342003, India.
Keywords
Related Articles
- EP ID EP1481
- DOI -
- Views 444
- Downloads 41
Formulation and evaluation of tramadol and diclofenac sodium multimodal sustain release tablet dosage form
Pain is treated using the unimodal pain management which are based on either central analgesic drug mechanism or other drug like nsaid. These drugs control the pain by central nervous system or peripheral nervous system....
Recent applications of nanodevices
Although the "war on cancer and other disease like AIDS" is now in its fourth decade and despite much progress has been made in categorizing the environmental causes and cellular and molecular biological basis for this d...
Development of proniosomes gel as a drug carrier for transdermal delivery of acyclovir
Non-ionic surfactant vesicles of acyclovir, an antiviral, were prepared by coacervation phase separation method. The prepared systems were characterised for encapsulation efficiency, shape, size and in vitro drug release...
Gastrointestinal mucoadhesive drug delivery system: an overview
The current article has been focused on the mucoadhesive drug delivery system. Mucoadhesive drug delivery system shows promising future in enhancing the bioavailability and specific needs by utilizing the physiological c...
DIETARY ANTIOXIDANTS TO PROP UP VIGOUR & VITALITY: AN OVERVIEW
One of the important objectives of modern health care, in addition to prevention of diseases, is the development of active treatments that control illnesses with minimum side effects to the body. Ayurvedic medicines, the...