FORMULATION AND EVALUATION OF DICLOFENAC NIOSOMAL DRUG DELIEVERY SYSTEMS
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2012, Vol 2, Issue 4
Abstract
In order to establish and maintain drugs from any concentrations at target sites for a longer period of time, niosomes was formulated. The main aim of this study was to formulate niosomal suspension containing diclofenac sodium multilamellar vesicle (MLVs). Diclofenac is a drug with narrow therapeutic index and short biological half-life. This study was aimed at developing and optimizing niosomal formulation of diclofenac in order to improve its bioavailability. In evaluation study the effect of the varying composition of non ionic surfactant and cholesterol on the properties such as encapsulation efficiency, particle size and drug release were studied. Moreover, the release of the drug was also modified and extended over a period of 72 h in all formulations. Different ratios of cholesterol and surfactant (span 20, span 40 and span 60) were used. The optimized ratio was 1:2:1 with highest entrapment efficiency. The in-vitro release of the drug was consistent. The time course of drugs and their effects in the body are assessed through pharmacokinetics which was provided by mathematical basis. The data collected from the release were incorporated into release kinetic analyses which are Higuchi equation and Korsmeyer‐Peppas equations. Further, release of the drug from the most satisfactory formulation NF-6 was evaluated through dialysis membrane to get the idea of drug release. The mechanism of dug release was governed by Peppas model.
Authors and Affiliations
Palash Das, Harika Das, M. Srujan Kumar, Arpita Ghosh, Dimple Kumari
Keywords
Related Articles
- EP ID EP223285
- DOI -
- Views 128
- Downloads 0
IN VITRO EVALUATION OF THE PHARMACOKINETIC ALTERATIONS CAUSED BY SULFAMETHOXAZOLE ON GLIMEPIRIDE HYDROXYLATION: PREDICTION OF THE IN VIVO DRUG DRUG INTERACTION FROM IN VITRO DATA.
The aim of this work was to investigate the effect of inhibition of CYP2C9 on the pharmacokinetics of glimepiride (GLM), with sulfamethoxazole (SMZ) as model inhibitor of CYP2C9 in vitro using human liver microsomes (HLM...
FORMULATION AND EVALUATION OF TACROLIMUS LOADED LIQUID CRYSTALLINE NANOPARTICLES
The use of liquid crystalline nanoparticles is a novel approach in the field of controlled drug delivery. Tacrolimus, being a highly lipophilic drug, is easily incorporated in the hydrophobic core of these nanoparticles....
EVALUATION OF MOMORDICA DIOICA SEED EXTRACT FORALPHA AMYLASE INHIBITORY ACTIVITY AND ANTIOXIDANT POTENTIAL IN RAT MODEL
Abstract The effect of ethylacetate extract of Momordica dioica seeds by in-vitro alpha amylase assay and in vivo anti-oxidant potential in streptozotocin induced diabetic rats was studied. Type II diabetes was induced i...
Formulation and Evaluation of Gastroretentive Floating Microballoons of Norfloxacin
The present study involves preparation and evaluation of floating microballoons with norfloxacin s model drug for prolongation of gastric residence time. The microballoons were prepared by the solvent evaporation method...
PRONIOSOMAL GEL A NOVEL APPROACH FOR DRUG DELIVERY: A REVIEW
Abstract One of the most important ways for non-invasive delivery of drugs is human skin. But some high molecular weight (> 500 Dalton) compounds can’t cross the skin. Such type of compounds require some novel techniques...