FORMULATION AND EVALUATION OF IMMEDIATE RELEASE EMTRICITABINE & TENOFOVIR DISOPROXIL FUMARATE TABLET
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 9
Abstract
The main purpose of the present study is to formulate and evaluate once daily an immediate release tablet of Emtricitabine and Tenofovir disproxil fumarate using different disintegrants. Preformulation studies were performed prior to compression. The tablets were compressed using Dicalcium phosphate, sodium starch glycolate, Lycatab-C, isopropylalcohol, glyceryl distearate and HPMC, Ideal blue (Y-30-1070) was used for coating the tablets. The fabricated tablets were evaluated for various properties like thickness, hardness, friability, disintegration time. Formulations were evaluated for the release of Emtricitabine and Tenofovir disproxil fumarate over a period of 45 min using United States Pharmacopoeia (USP) type-II dissolution apparatus. The in-vitro drug release study, T-VI exhibited satisfactory drug release. Sodium starch glycolate is found to be the better disintegrant when compared to Lycatab-C .Compared to the direct compression, wet granulation was found to be the best method of choice for formulation of these tablets.
Authors and Affiliations
Kotta Kranthi Kumar*| Department of Pharmaceutics, SKU College of Pharmacutical Sciences, S.K.University, Anantapur, India, Sravanthi. Morae| Department of Pharmaceutics, SKU College of Pharmacutical Sciences, S.K.University, Anantapur, India, M. Sabareerh| A.P, Krishna Teja Pharmacy College Tirupathi, India
Keywords
Related Articles
- EP ID EP1450
- DOI -
- Views 523
- Downloads 52
A review on pathophysiology and treatment of aplastic anaemia
Aplastic anaemia is a medical condition in which the bone marrow is fails to make enough blood cells such as RBC, WBC & Platelets. It is mostly 2 types such as acquired and inherited and it is caused by exposure to chemi...
PREPARATION AND EVALUATION OF ZIDOVUDINE NANOPARTICLES
Nanoparticles represent a promising drug delivery system of controlled and targeted drug release. They are specially designed to release the drug in the vicinity of target tissue. The aim of this study was to prepare and...
A study on nutritional status of adolescent girls with reference to BMI among school going adolescent girls, Chidambaram.
Introduction: Adolescence is a crucial period of important distinctions together with physiological, physical, behavioral and social changes. Under-nutrition among adolescent girls is a major public health problem unsoun...
OPHTHALMOMYIASIS EXTERNA CAUSED BY SHEEP BOTFLY (OESTRUS OVIS) LARVA: RARE CASE REPORT
Ophthalmic myiasis is due to deposition of fly larvae in the human eye. Various species of flies are able to provoke ophthalmomyiasis, including, Oestrus ovis , latrine fly (Fannia), house fly (Musca domestica), and catt...
Drug Addiction in Vindhyan Population of Madhya Pradesh: a Socio-economic and Health Perspective
In Indian society the problem of intoxication, inebriation is a faster growing bug. This bug mostly grab illiterate person, socially enigmatic person, unemployed person, workers and laborers which leads to serious health...