FORMULATION AND EVALUATION OF IMMEDIATE RELEASE EMTRICITABINE & TENOFOVIR DISOPROXIL FUMARATE TABLET
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 9
Abstract
The main purpose of the present study is to formulate and evaluate once daily an immediate release tablet of Emtricitabine and Tenofovir disproxil fumarate using different disintegrants. Preformulation studies were performed prior to compression. The tablets were compressed using Dicalcium phosphate, sodium starch glycolate, Lycatab-C, isopropylalcohol, glyceryl distearate and HPMC, Ideal blue (Y-30-1070) was used for coating the tablets. The fabricated tablets were evaluated for various properties like thickness, hardness, friability, disintegration time. Formulations were evaluated for the release of Emtricitabine and Tenofovir disproxil fumarate over a period of 45 min using United States Pharmacopoeia (USP) type-II dissolution apparatus. The in-vitro drug release study, T-VI exhibited satisfactory drug release. Sodium starch glycolate is found to be the better disintegrant when compared to Lycatab-C .Compared to the direct compression, wet granulation was found to be the best method of choice for formulation of these tablets.
Authors and Affiliations
Kotta Kranthi Kumar*| Department of Pharmaceutics, SKU College of Pharmacutical Sciences, S.K.University, Anantapur, India, Sravanthi. Morae| Department of Pharmaceutics, SKU College of Pharmacutical Sciences, S.K.University, Anantapur, India, M. Sabareerh| A.P, Krishna Teja Pharmacy College Tirupathi, India
Keywords
Related Articles
- EP ID EP1450
- DOI -
- Views 493
- Downloads 52
ARTEROLANE MALEATE AND PIPERAQUINE PHOSPHATE: A NEW OPTION IN THE TREATMENT OF PLASMODIUM FALCIPARUM MALARIA
Malaria is holoendemic in India, claiming thousands of deaths annually. Recent data suggests that the burden of malaria, the most significant parasitic disease in the world, is increasing. India’s expansive geography and...
SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF SOME 1,3,4-OXADIAZOLE DERIVATIVES WITH BENZOXAZOLE MOIETY
Synthesis of 1,3,4-oxadiazole derivatives has attracted considerable attention in view of therapeutic applications. In the presented research work, a series of novel 5-substituted-1,3,4-oxadiazole-2-thiol containing pipe...
“A CLINICAL STUDY TO EVALUATE THE EFFECTIVENESS OF AN AYURVEDIC INDIGINOUS COMPOUND IN CASES OF URDHWAGA AMLAPITTA w.s.r GERD”
Aim: To evaluate the efficacy of an ayurvedic indigenous compound in cases of urdhwaga amla-pitta. Introduction: Amla-pitta is one of the common clinical problems of our day to practice and it is increasing rapidly due t...
STUDY ON CONSERVATIVE TREATMENT IN EARLY OTHEMATOMA IN A TERTIARY CARE HOSPITAL IN EASTERN INDIA
OBJECTIVES: To evaluate a conservative treatment strategy in othematoma. METHODS: Study was done with 31 patients with othematoma. These patients were treated in “outpatient department” with aspiration of hemarregic flui...
Formulation and Evaluation of Nanosilver Loaded Silk Fibroin Topical Gel
The skin is providing barrier to the outside protecting the body from infection, radiation, and extremes of temperature. There are various types of wounds which can damage the skin including abrasions, lacerations, rupt...