FORMULATION AND EVALUATION OF IMMEDIATE RELEASE EMTRICITABINE & TENOFOVIR DISOPROXIL FUMARATE TABLET
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 9
Abstract
The main purpose of the present study is to formulate and evaluate once daily an immediate release tablet of Emtricitabine and Tenofovir disproxil fumarate using different disintegrants. Preformulation studies were performed prior to compression. The tablets were compressed using Dicalcium phosphate, sodium starch glycolate, Lycatab-C, isopropylalcohol, glyceryl distearate and HPMC, Ideal blue (Y-30-1070) was used for coating the tablets. The fabricated tablets were evaluated for various properties like thickness, hardness, friability, disintegration time. Formulations were evaluated for the release of Emtricitabine and Tenofovir disproxil fumarate over a period of 45 min using United States Pharmacopoeia (USP) type-II dissolution apparatus. The in-vitro drug release study, T-VI exhibited satisfactory drug release. Sodium starch glycolate is found to be the better disintegrant when compared to Lycatab-C .Compared to the direct compression, wet granulation was found to be the best method of choice for formulation of these tablets.
Authors and Affiliations
Kotta Kranthi Kumar*| Department of Pharmaceutics, SKU College of Pharmacutical Sciences, S.K.University, Anantapur, India, Sravanthi. Morae| Department of Pharmaceutics, SKU College of Pharmacutical Sciences, S.K.University, Anantapur, India, M. Sabareerh| A.P, Krishna Teja Pharmacy College Tirupathi, India
Keywords
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