Fundamental aspects of cardiovascular regulation in predisposition to atrial fibrillation

Journal Title: Moldovan Medical Journal - Year 2018, Vol 61, Issue 4

Abstract

Background: Atrial fibrillation is the most common sustained arrhythmia in cardiology. The structural factors leading to atrial fibrillation are well known, but there should be also regarded the functional factors. In 2014, the Task Force published guidelines for atrial fibrillation describing the importance of the vegetative nervous system in creating predisposition to atrial fibrillation although it describes that the mechanism is not completely clear. Furthermore, it is important to understand this mechanism, regarding the increasing number of patients affected by atrial fibrillation without any structural heart diseases. The aim of this work is to understand the physiological background of the predisposition to the appearance and recurrence of atrial fibrillation regarding the role of neural regulatory systems of the heart, especially when no structural heart diseases are present. Therefore, the following is a fundamental analysis of the neural regulation of heart rhythm, including the vegetative nervous system at its medullar and central levels and also the cerebral cortex input in heart regulation. Conclusions: The predisposition to atrial fibrillation regarding the neural regulatory systems of the heart can be pinpointed to three key factors: 1. Central over-activity; 2. Sympathetic efferent overflow towards the heart in rest state; 3. Parasympathetic exhaustion and break-down of the parasymphatetic protective function.

Authors and Affiliations

Ludmila Sidorenko, Ivan Diaz-Ramirez, Victor Vovc, Gert Baumann

Keywords

Related Articles

The stable-functional osteosynthesis of clavicular fractures with external fixator

Background: Over the past two decades has been paid insufficient attention to the treatment of patients with clavicle fractures. Analysis is of the recent available literature and the personal practice allow us to have a...

Risk factors in the development of acute appendicitis complications

Background: To study the risk factors of the development of acute appendicitis (AA) complications in adults in order to improve the results of surgical treatment. Material and methods: The research included 449 patients...

Markers of apoptosis and oxidative stress in congestive heart failure

Background: The aim of this work is to study the markers of apoptosis (granzyme B) and oxidative stress (nitric oxide), as well as indicators of endothelial damage - cystatin C and lipid metabolism in patients with conge...

Prevalence of primary headaches in adolescents

Background: The aim of this study was to estimate overall prevalence of primary headaches and prevalence of migraine (MG) and tension-type headache (TTH) among adolescents in the Republic of Moldova. Metetial and methods...

Comparative results in the treatment of clavicle fractures

Background: The negative results of the clavicle fractures treatment represent a high percentage, which implies the search of new methods designed to improve these results. Thus, a new method of stable and functional ost...

Download PDF file
  • EP ID EP479469
  • DOI 10.5281/zenodo.2222313
  • Views 333
  • Downloads 0

How To Cite

Ludmila Sidorenko, Ivan Diaz-Ramirez, Victor Vovc, Gert Baumann (2018). Fundamental aspects of cardiovascular regulation in predisposition to atrial fibrillation. Moldovan Medical Journal, 61(4), 42-45. https://europub.co.uk/articles/-A-479469