Gastroprotective activity of ethanolic bark extract of prunus persica against expreimentally induced gastric ulcer in rats
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2018, Vol 7, Issue 2
Abstract
The aim of the study is to evaluate the gastroprotective activity of ethanolic bark extract of Prunus persica (EBPP) against NSAID plus pylorus ligation induced gastric damage in rats. 10 to 20% of world population trust medicinal herbs for treating the diseases as they believe to have less side effects. Prunus persica is a rich source for flavonoids and various parts of the plant are used as medicinal agents in traditional medicine. Ethanobotanical survey reveals the antiulcer property of Prunus persica bark. The rats were divided into four groups as control, reference control (Misoprostol), EBPP 200 and 400mg/kg with six rats in each group. Gastric lesions were induced by oral administration of indomethacin (20 mg/kg) followed by pylorus ligation. Standard group of animals were treated with misoprostol and test group of animals were treated with EBPP at doses of 200 and 400 mg/kg. Gastroprotective activity of extract was determined by mean Gastric volume, Ulcer index, Free acidity and Total acidity. Gastric volume, Ulcer index, Free Acidity and Total Acidity were significantly decreased by both the doses of EBPP as compared to control group. From the result it was concluded that, the ethanolic bark extract of Prunus persica showed gastroprotective activity in dose dependant manner against NSAID plus pylorus ligation induced gastric ulcer in rats.
Authors and Affiliations
Baskaran Kaliappan
Keywords
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