Genetics of Type 2 Diabetes- A Review Article
Journal Title: Iranian Journal of Diabetes and Obesity - Year 2016, Vol 7, Issue 4
Abstract
Objective: Type 2 diabetes (T2D) as a complex disease is the result of genetically heterogeneous factors and environmental issues interaction. Linkage and small-scale candidate gene studies were successful in identification of genetic susceptibilities of monogenic form of diseases. However, they were largely unsuccessful while applying to the more common forms of disease. By designing Genome Wide Association studies (GWAs), the new windows open to genetic approaches. So far, around 153 variant were discovered for T2D and missing rare variants are waiting to be discovered. The new findings are beneficial to explain molecular signaling and pathways responsible for pathophysiology of T2D, which offered opportunities for the development of novel therapeutic and preventive tactics. The GWAs findings need to be confirmed in on going researches. In this review, we address, genetic susceptibilities related to T2D since 2007. Also challenge advantages and disadvantages of GWAs and discuss about the next confirmatory approaches need to be done.
Authors and Affiliations
Ensieh Shahvazian, Ehsan Farashahi Yazd, Mohammad Hasan Sheikhha, Masoud Rahmanian
Editor’s note:
An article entitled “Depression and Glycemic Control in Type II Diabetic Patients” was published in volume 7, number3 2015 with the wrong author list: Seyed Mostafa Seyed Hosseini, Alireza Mardan...
Seasonal Changes of HbA1c Levels in Type 2 Diabetes Mellitus Patients
Objective: There are changes in plasma glucose and HbA1c of type 2 diabetes mellitus (T2DM) patients in different seasons. HbA1c levels may increase during winter season in most T2DM patients without weight gain. In this...
Effects of Hydro-Alcoholic Leaf Extract of Kardeh (Biarum Bovei Blume) on the Blood Glucose and Lipid Peroxidation in Cerebral Tissues and Lipid Profile in Streptozotocin Induced Diabetic Rats
Objective: Oxidative stress is the result of an imbalance between free radical production and antioxidant defenses of the body. The use of antioxidants can have preventive effects in diabetes. The present study aims to s...
The Effect of 6 Weeks Resistance Training and HITT on GLP-1 Gene Expression of Diabetic Rats
Objective: Cardiovascular diseases are the main reason of the death in type 2 diabetic patients. The purpose of this study was to evaluate the effect of 6 weeks of resistance training and HITT (High Intensity Interval Tr...
Relationship between Infant Feeding and Obesity and Overweight in Young Adulthood
Objective: Overweight and obesity described as the most serious public health issues that can lead to long-term consequences .This study conducted to investigate whether breastfeeding has a preventing effect on the preva...