Glibenclamide fabricated transdermal wafers for therapeutic sustained delivery systems

Abstract

Transdermal wafers of the Glibenclamide (GBE) were developed employing Ethyl cellulose (EC) and Hydroxypropyl methylcellulose (HPMC), Ethyl cellulose and Polyvinyl pyrrolidone (PVP) as a film former. The effect of binary mixture of polymer and penetration enhancer on physicochemical parameters including thickness, weight variation, drug content, and in vitro permeation was evaluated. In vitro skin permeation study was conducted on the rat abdominal skin as a penetration barrier in Franz diffusion cell from the binary mixtures. EC/HPMC (8.5:1.5) and EC/PVP (3:2) combination showed the good permeability. The incorporation of penetration enhancer the binary mixture further enhances the permeability.

Authors and Affiliations

Prabhu Narayan Yadav Priyanka Bhat , Shashank Soni

Keywords

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  • EP ID EP31468
  • DOI -
  • Views 336
  • Downloads 1

How To Cite

Prabhu Narayan Yadav Priyanka Bhat, Shashank Soni (2014). Glibenclamide fabricated transdermal wafers for therapeutic sustained delivery systems. International Journal of Pharmaceutical and Medicinal Reserach, 2(2), -. https://europub.co.uk/articles/-A-31468