Glomerulonephritis associated with monoclonal gammopathy: two cases
Journal Title: Dokuz Eylul Universitesi Tip Fakultesi Dergisi - Year 2017, Vol 31, Issue 3
Abstract
Plasma cell diseases or monoclonal gammopathies are group of disorders which occur as a result of uncontrolled proliferation of plasma cells and over production of immunglobulins. One of the important problems encountered in plasma cell disorders is renal diseases. Herein, we present two different cases of glomerulonephritis which are associated with monoclonal gammopathy.study. Both the scale and the data collection sheet was applied to the students in classess or in a study environment. First case was a 51 year-old-man with anemia, acute renal failure (ARF) and isolated microscopic hematuria whom were referred to nephrology outpatient clinic. He had no history of hypertension (HT), diabetes mellitus (DM), renal disease and nephrotoxic drug usage. Renal biopsy was done and diagnosed as C3 glomerulonephritis (C3GN). Second case was a 69 year-old-man whom had a history of chronic renal failure (CRF), HT, DM and chronic ischemic heart disease. He had a progressively increased proteinuria for a one year during the nephrology outpatient clinic follow-up. He had nephrotic proteinuria and no hematuria. Atypical proteinuria was considered. Renal biopsy was done and diagnosed as membranoproliferative glomerulonephritis (MPGN). Both of the cases were investigated for monoclonal gammopathy during the inpatient clinic follow-up. A sharp band was detected in protein electrophoresis and IgG-Kappa monoclonal gammopathy was observed in immunfixation in both of the cases. Bone marrow aspiration and biopsy were done and diagnosed as multiple myeloma. The circulating paraproteins cause a diversity of kidney diseases and they can affect the glomeruli especially. If patient is diagnosed as MPGN or C3GN, secondary reasons including the monoclonal gammopathies must be absolutely investigated.
Authors and Affiliations
Serkan YILDIZ, Evrim BOZKAYA, Mehtat ÜNLÜ, Mehmet Ali ÖZCAN, Caner ÇAVDAR, Aykut SİFİL, Ali ÇELİK, Sülen SARIOĞLU, Taner ÇAMSARI
Keywords
Related Articles
- EP ID EP413218
- DOI 10.5505/deutfd.2017.93685
- Views 78
- Downloads 0
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