Glycemic Control And Raised Adenosine Deaminase Activity In Type 2 Diabetes Mellitus
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 1
Abstract
Background: Metabolic disturbance and immunological imbalance are the key factors in the pathogenesis of Type 2 Diabetes Mellitus. In the present study we measured Plasma Adenosine Deaminase (ADA) activity, a marker of cell mediated immunity in Type 2 Diabetics with Good and Poor glycemic control. Materials & Methodology: The study included 25 Type 2 diabetic patients with good glycemic control (HbA1c<7), 25 Type 2 diabetic patients with poor glycemic control (HbA1c>7) and 30 healthy controls with no history of diabetes mellitus. Fasting Blood sugar, HbA1c and Plasma ADA activity were estimated in all these subjects. Results: Overall an elevation of plasma ADA activity was observed in Type 2 diabetic subjects as compared to controls. In particular when compared to control group, much higher ADA activity was observed in Type 2 diabetic patients with poor glycemic control than Good Glycemic control (p<0.01). Significant Positive correlation was also observed between ADA & HbA1c in both good (r=0.67, P<0.01) and poor glycemic controls(r=0.645, P<0.01). Conclusion: The significant raise of ADA activity with raise in HbA1c reflects activation of cell mediated immune response as a defense mechanism owing to deterioration of glycemic control in Type 2 diabetic patients.
Authors and Affiliations
Hariprasath . G, Ananthi . N
Keywords
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- EP ID EP590685
- DOI 10.9790/0853-1601095356.
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