Granulocyte Therapy for Cancer: A Prospective Review
Journal Title: Science Insights - Year 2014, Vol 7, Issue 1
Abstract
A powerful and complicated defense system exists within the cell and the whole body to protect against “irresponsible” cell growth and to deal harshly with most wannabe cancerous cells. However, occasionally the malfunction of one of these systems may result in an uncontrolled cell growth, which has been found taking the first step toward becoming carcinogenesis. Immune system is the most important defense system to protect the host from diseases. There is strong evidence showing that immune system also plays an essential role in providing significant protection against cancer. However, how the immune system works in defending and fighting against cancer and what is the exact molecular mechanisms of this process are still unknown. We herein review the historical change of the immune-associated cancer therapy and then provide evidence on the exploration of the relationship between the immune system and cancer disease. Moreover, an outline about the serendipity discovery of the Spontaneous Regression/Complete Resistant mice and the corresponding selective cancer killing mechanism of which is mediated entirely by leukocytes from the innate immunity is discussed. In addition, based on the outstanding curative effect on the animal model, a promising anti-tumor therapy method, Leukocyte Infusion Therapy, has been approved by FDA and is being preceded in conducting clinical trials.
Authors and Affiliations
Dong Wang
Keywords
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- EP ID EP689543
- DOI 10.15354/si.14.re009
- Views 170
- Downloads 1
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