HEPATOPROTECTIVE ACTIVITY OF SHARBAT CHYLOSIN A POLYHERBAL FORMULATION AGAINST CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN RATS
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 9
Abstract
Carbon tetrachloride (CCl4) is the most commonly used hepatotoxin agents in the experimental studies for evaluate hepatoprotective activity. The present study was designed to evaluate the hepatoprotective activity of Sharbat Chylosin on CCl4 induced hepatotoxicity in Male Long-Evans albino rats. Group I served as normal control and received neither formulation nor carbon tetrachloride. Group II received a suspension of CCl4 in liquid paraffin in a ratio of 2:1 (v/v) in an uniform dose of 1 ml/kg body weight intraperitoneally for consecutive 14 days. Group III and IV received CCl4 1ml/kg body weight intraperitoneally plus Silymarin, in dose 50 mg/kg orally and Sharbat Chylosin 1ml/kg body weight of rat respectively for the same 14 consecutive days. End of study hepatoprotective activity was determination by the levels of total bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP). Histopathological study also carried out on rat liver. The result showed that polyherbal formulation exhibited a significant hepatoprotective effect by total bilirubin, ALT, AST and ALP when compared with standard Silymarin. Good hepatoprotection also showed in histopathological study. Therefore this study suggests that Sharbat Chylosin might be beneficial in CCl4 induced hepatotoxicity and may be attributed to the antioxidant properties of selected polyherbal formulation.
Authors and Affiliations
Dr. Md. Nazmul Huda
Keywords
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