Hereditary prostate cancer
Journal Title: Postępy Nauk Medycznych - Year 2015, Vol 28, Issue 1
Abstract
Epidemiologic research conducted over the last two decades has led us to believe that inherited factors play an important role in the etiology of prostate cancer, but the genes, which underlie the inherited susceptibility are elusive. In Poland, we have initiated a program to identify DNA variants, which confer an increased risk of prostate cancer. We found that germline mutations in CHEK2, NBS1, HOXB13 and the rs188140481 variant in the 8q24 region confer an increased prostate cancer risk in Polish men. Our studies provide evidence that the list of known genetic markers of high risk of prostate cancer can be extended by these specific variants in men with a positive family history of prostate cancer in at least one first or second degree relative (the risk increased about 3-8 fold). Based on our findings, we recommend that genetic testing for prostate cancer susceptibility in Poland be based on the seven founder alleles (IVS2 + 1G > A, 1100delC, del5395, I157T in CHEK2; 657del5 in NBS1; G84E in HOXB13; allele A of rs188140481). Identification of genetic markers of prostate cancer susceptibility will improve prevention, diagnosis and management of prostate cancer in Poland.
Authors and Affiliations
Cezary Cybulski, Aniruddh Kashyap, Wojciech Kluźniak, Dominika Wokołorczyk, Adam Gołąb, Marcin Słojewski, Bartosz Gliniewicz, Andrzej Antczak, Jan Lubiński
Keywords
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