Hypocaloric diet and pharmacological treatment reduces body weight, insulin resistance and androgen levels and restore menstruation in obese women with polycystic ovary syndrome
Journal Title: Postępy Nauk Medycznych - Year 2010, Vol 23, Issue 8
Abstract
Objective. To estimate the effects of the hypocaloric diet and pharmacological treatment with sibutramine on body weight, fat mass, especially abdominal fat, insulin resistance, serum androgens and menstruation pattern in overweight and obese women with polycystic ovary syndrome.Material and methods. 20 females with PCOS aged 19 – 49 years with BMI 27,3-53,8 kg/m2 studied before and after 1,3 and 6 months of the treatment with hypocaloric diet and sibutramine 10-15 mg/day. Measurement included body weight, BMI, waist circumference, total and trunk fat mass, glucose, insulin, blood lipids, androgens, LH,FSH, estradiol, fT4, TSH and menstrual pattern.Results. Body weight, BMI and waist circumference significantly decreased already after 1st month (p<0,001) and were decreasing further during next months. Fat mass decreased of 9,2% (p<0,001) and fat mass of the trunk of 8,2% (p<0,001) after 6 months. In the same time significant decrease in serum fasting glucose (p<0,01), insulin (p<0,01), total cholesterol (p<0,01), LDL-cholesterol (p<0,05) and triglicerydes (p<0,01) were observed. HDL-cholesterol increased significantly (p<0,001). Throughout the study serum testosterone, androstendione and DHEA-S levels decreased significantly (p<0,01; p<0,05 and p<0,001, respectively). Menstrual bleedings reoccurred in eighteen women throughout the study.Conclusions. Hypocaloric diet plus pharmacological treatment with sibutramine caused a significant weight loss, had beneficial effects on some metabolic and cardiovascular risk factors, reduced androgens and restored menstruations in overweight and obese women with polycystic ovary syndrome.
Authors and Affiliations
Jarosław Kozakowski , Wojciech Zgliczyński
Keywords
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