Hyponatremia Induced by Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers-A Pilot Study
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 7
Abstract
Introduction: Hyponatremia, serum sodium <135 mmol/L, can result in neurological manifestation in acute cases, may lead to seizures and coma. Angiotensin Converting Enzyme Inhibitor (ACEI) and Angiotensin II Receptor Blockers (ARB) are drugs that have been commonly prescribed for the treatment of hypertension and cardiac diseases. It has become important to evaluate and investigate the incidence of hyponatremia on consumption of these drugs. Aim: To determine the susceptibility of patients on ACEI and ARB to hyponatremia and to ascertain the drug producing notable hyponatremia among ACEI and ARB. Materials and Methods: The study was conducted in a tertiary care hospital. Serum sodium levels were assayed in patients taking ACEI and ARB; 50 patients were recruited. The patient’s age, sex, drug dosage, frequency of the drug administration were collected using a proforma. Statistical analysis of data were performed using SPSS version 19.0. Results: Among all, 48% (24 out of 50) of the study population administered with ACEI and ARB developed hyponatremia. Predisposition to develop hyponatremia was high in males compared to females. Incidence of hyponatremia was 62.5% (10 out of 16) in the age group of 56-75 years. Though, incidence of hyponatremia was 54.5% (18 out of 33) in ACEI group compared to 35.2% (6 out of 17) in ARB group, but it was not statistically significant. The study also revealed that metosartan had a higher association with hyponatremia compared to other drugs. Conclusion: Hyponatremia was induced in nearly 50% of patients taking ACEI and ARB. The incidence of hyponatremia among patients on these two drugs did not show statistical variation. Metosartan showed a higher incidence of hyponatremia compared to enalapril, ramipril, captopril, telmisartan, losartan included in the study. This study revealed that monitoring of serum sodium level in the patients with ACEI and ARB administration will help to elude unexpected adverse reactions.
Authors and Affiliations
S Bhuvaneshwari, Prakash Vel Sankhya Saroj, D Vijaya, M Sabari Sowmya, R Senthil Kumar
Keywords
Related Articles
- EP ID EP523150
- DOI 10.7860/JCDR/2018/31983.11754
- Views 85
- Downloads 0
Role of X-linked Inhibitor of Apoptosis Protein as Cancer Biomarker
X-linked Inhibitor of Apoptosis Protein (XIAP), is one of the most important apoptotic inhibitors that plays a vital role in regulating various aspects of cell functions including cell cycle progression, arrest, and apop...
Mammary Analogue Secretory Carcinoma- A Salivary Gland Neoplasm: Case Report of an Exceptionally Rare Tumour
ABSTRACT Mammary Analogue Secretory Carcinoma (MASC) is a rare salivary gland tumour. It clinically presents as a painless mass in the parotid gland affecting mainly males. A 17-year-old male presented with 18 month hist...
Study on the Use of Methylene Blue Spray in Identification of Recurrent Laryngeal Nerve During Thyroid Surgery
ABSTRACT Introduction: Thyroidectomy is one of the most commonly performed surgeries in iodine deficient regions. Injury to parathyroids and Recurrent Laryngeal Nerve (RLN) are two of the complications of thyroidectomy t...
Case of Extreme Trichotillomania in a Child with Comorbidities
ABSTRACT Trichotillomania is an uncommon paediatric psycho-dermatological condition in children. Contrary to the prevalence reported in western literature, it is relatively uncommon in paediatric clinics of Indian subcon...
Portal Vein Pseudoaneurysm: A Rare Complication of Post Pancreaticoduodenectomy Haemorrhage
ABSTRACT Pancreaticoduodenectomy is a complex procedure which is associated with high rates of mortality and morbidity. With the improvement of surgical techniques and skills the mortality rates have come down drasticall...