In vitro and in vivo potentiation of ampotericin-B by flavonoid against different fungal strains
Journal Title: Journal of Research in Biology - Year 2016, Vol 6, Issue 4
Abstract
Synergistic effects of 18 flavonoids (11 glycosides and flavones, 01 flavones diglycoside, 04 chalcones and 02 aglycones) in combination with different anti-fungal agents against fungal strains were investigated. The agar diffusion assay of these flavonoids with different anti-fungal agents was tested. The Minimum Inhibitory Concentration (MIC) values of each of the flavonoids with different anti-fungal agents were determined by using checkerboard broth micro dilution assay. Flavones diglycoside (3, 5-dihydroxy flavones 7-O-b-D-glucuronide-4-O-b-D-glucopyranside) potentiated the in vitro and in vivo activity against fungal strains. The flavones diglycoside reduced MIC of amphotericin-B to one half against different fungal strains, Candida albicans, Candida krusei, Candida parapsilosis, Candida tropicalis and Cryptococcus neoformans 1202. Although moderate change between in vitro and in vivo studies have been found, the elucidation of the mechanisms involved in flavonoid action will have many health benefits to man. In conclusion, these findings suggested that flavonoid combination regimens may be considered as an useful candidate for the treatment of fungal infection
Authors and Affiliations
Zahid Mahmood, Vijeshwar Verma, Inshad Ali khan, Mohmmad Afzal Zargar
Keywords
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