Ligand Binding Assays in the 21st Century Laboratory: Recommendations for Characterization and Supply of Critical Reagents

Journal Title: The AAPS Journal - Year 2012, Vol 14, Issue 2

Abstract

The online version of this article (doi:10.1208/s12248-012-9334-9) contains supplementary material, which is available to authorized users.

Authors and Affiliations

Denise M. O’Hara, Valerie Theobald, Adrienne Clements Egan, Joel Usansky, Murli Krishna, Julie TerWee, Mauricio Maia, Frank P. Spriggs, John Kenney, Afshin Safavi, Jeannine Keefe

Keywords

Related Articles

Are Physiologically Based Pharmacokinetic Models Reporting the Right Cmax? Central Venous Versus Peripheral Sampling Site

The online version of this article (doi:10.1208/s12248-015-9796-7) contains supplementary material, which is available to authorized users.

Equivalence studies for complex active ingredients and dosage forms

This article examines the United States Pharmacopeia (USP) and its role in assessing the equivalence and inequivalence of biological and biotechnological drug substances and products—a role USP has played since i...

Performance and Robustness of the Monte Carlo Importance Sampling Algorithm Using Parallelized S-ADAPT for Basic and Complex Mechanistic Models

The Monte Carlo Parametric Expectation Maximization (MC-PEM) algorithm can approximate the true log-likelihood as precisely as needed and is efficiently parallelizable. Our objectives were to evaluate an importance sampl...

New questions regarding bioequivalence of levothyroxine preparations: A Clinician's response

A recent decision by the Food and Drug Administration (FDA) to declare various brands of levothyroxine bioequivalent has provoked objections from several physicians' organizations. These organization assert that the meth...

Microdialysis as a tool in local pharmacodynamics

In many cases the clinical outcome of therapy needs to be determined by the drug concentration in the tissue compartment in which the pharmacological effect occurs rather than in the plasma. Microdialysis is an in vivo t...

Download PDF file
  • EP ID EP681220
  • DOI  10.1208/s12248-012-9334-9
  • Views 61
  • Downloads 0

How To Cite

Denise M. O’Hara, Valerie Theobald, Adrienne Clements Egan, Joel Usansky, Murli Krishna, Julie TerWee, Mauricio Maia, Frank P. Spriggs, John Kenney, Afshin Safavi, Jeannine Keefe (2012). Ligand Binding Assays in the 21st Century Laboratory: Recommendations for Characterization and Supply of Critical Reagents. The AAPS Journal, 14(2), -. https://europub.co.uk/articles/-A-681220