Liver Biopsy Study in Diseases of Paediatric Age Group
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 3
Abstract
To determine pattern of liver disease in the paediatric age group. Materials and Methods: In the present study of 28 cases (including 5 postmortem biopsy), liver biopsy was done, out of which 24 cases could be diagnosed histologically .Slides were prepared from paraffin-embedded blocks, stained by routine H & E and special stains and were then reviewed. The frequency of each disorder, separately and in combination with the age group or gender of the patients was calculated and compared with other similar studies. Results: Incidence of liver involvement was slightly more (58.3%) in males. The most common age group which suffered from liver disease was 2-6 yrs (66.7%). The commonest cause of hepatomegaly was cirrhosis of liver (57.1%) followed by malnutrition (14.3%), chronic venous congestion (9.5%). Hyperbilirubinemia was present in 75% children of I.C.C., 50% children of post hepatitis cirrhosis and 25% of early cirrhosis. Overall it was seen in 46.7% children of cirrhosis.Liver biopsy is an essential diagnostic tool in various liver disorders, in that only in 62.6 % of our cases clinical diagnosis was consistent with histopatholgical changes. Liver biopsy is an essential diagnostic tool especially in cases of unknown hepatomegaly where diagnosis can only be done after histopathological study of liver tissue.
Authors and Affiliations
Dr Dileep Kumar Jain, Dr Malay Bajpai, Dr Vivek Gupta
Keywords
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- EP ID EP591261
- DOI 10.9790/0853-1603011519
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