Long-Term Steroid-Based Therapy: Risk of Infectious Complications in Immunosuppressed Kidney-Transplant Recipients as Compared to the General Population
Journal Title: Open Access Journal of Urology & Nephrology - Year 2017, Vol 2, Issue 2
Abstract
Steroids are used to treat chronic inflammatory diseases and are often given as part of an immunosuppressive therapy to prevent acute/chronic kidney-graft rejection. However, steroids have many side-effects and may increase the risk of infectious complications. This review reports on the infectious complications that occur in those within the general population that receive chronic steroid therapy compared to kidney-transplant recipients that receive steroids as part of their immunosuppressive regimen. Many studies show that patients with rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, or inflammatory bowel disease, and treated for >90 days with a steroid-based therapy, have a significantly greater likelihood of developing a serious infectious complication. However, kidney-transplant recipients that receive long-term steroid therapy, when compared to those with steroid-free immuno suppression, have the same risk of developing an infectious complication: this may be because the current immunosuppressive drugs, such calcineurin inhibitors and mycophenolic acid, are so powerful that they offset the risks linked to steroids.
Authors and Affiliations
Lionel Rostaing
Keywords
Related Articles
- EP ID EP498816
- DOI 10.23880/oajun-16000124
- Views 40
- Downloads 0
Male Infertility- Current Concepts and Advances in Evaluation and Management- A Review
Globally Infertility and problems of impaired fecundity have been a concern. Which affects 8-12% of couples worldwide of all infertility cases, approximately 40-50% is due to “male factor” infertility and as many as 2% o...
Hepcidin, Selenium and Superoxide Dismutase in Oxidative Stress and in Dialysis Patients
Chronic kidney diseases (CKDs) are characterized by complex changes in cellular metabolism, leading to oxidative stress (OS), i.e. increased production of oxidative radicals (OR), which can play a key role in a number of...
Malone Procedure Combined with Mitrofanoff Using a Divided Appendix and Vesical Enlargement Description of the Surgical Technique and Case Report
Surgical treatment for neurogenic bladder has evolved notably. A great number of patients with neurogenic bladder also present fecal incontinence and treatment for these patients is discouraging. With the induction and u...
Utilization of the Charlson Comorbidity Score to Predict 10-Year Survival in Renal Transplant Recipients
Purpose: The Charlson Comorbidity Score has been demonstrated to predict mortality in prostate cancer patients. Our novel objective was to compare the 10-year observed mortality with expected mortality based on pre-opera...
Urological Presentation in Zika Virus Infection: A Forgotten Issue
Zika virus infection is an important problem at present. The clinical presentation of Zika virus infection is usually mild or asymptomatic but it can also induce the neurological complication and teratogenic problem. In...