Low body mass index increases risk of anemia in patients with HIV-AIDS receiving antiretroviral therapy

Journal Title: Universa Medicina - Year 2017, Vol 36, Issue 3


Background In acquired immunodeficiency syndrome (AIDS) cases, cytopenias of all major blood cell lines were increasingly recognized in patients with HIV infection. Anemia commonly occurs during HIV infection and has been associated with increased progression to AIDS and decreased survival. The aim of this study was to determine the prevalence of anemia and associated risk factors in adults with HIV-AIDS receiving antiretroviral therapy (ART). Methods A cross sectional study was conducted involving 90 adults with HIV-AIDS. Sociodemographic data were collected using a questionnaire. In all patients, CD4+ lymphocyte counts were performed by means of a PIMA analyzer, while hemoglobin was determined using a Sysmex hematology analyzer. The WHO cutoff value of hemoglobin was adjusted to altitude to define anemia. Mild to moderate anemia was defined as hemoglobin 8-13 g/dL for men and 8-12 g/dL for women. Severe anemia was defined as hemoglobin 8 g/dL. Data was analyzed by using logistic regression test. Results There were 90 subjects with HIV-AIDS in this study. Anemia was found in 50 subjects (55.6%), consisting of 12.2% with mild anemia and 43.4% with moderate to severe anemia. Multiple logistic regression showed that an important risk factor for anemia was low body mass index (BMI) between <17-18.5 (OR=4.20; 95% CI=1.23-14.36). However, the CD4 <350 cells/mm3 was not a significant risk factor for anemia (OR=1.03; 95% CI=0.21-5.04). Conclusions Low BMI increases the risk of anemia in subjects with HIV receiving ART. Better screening for anemia and infectious diseases, and modified harm reduction strategy for injection drug users are primary needs in HIV patients.

Authors and Affiliations

Mirna Widiyanti, Reynold Ubra, Eva Fitriana


Related Articles

Contact with poultry and animals increases risk of Campylobacter infections in adults of Ardabil province, Iran

Background The acute gastroenteritis caused by campylobacteriosis is known as one of the common infectious diseases with worldwide distribution. The aim of this study was to detect Campylobacter species in stool samples...

Tumor necrosis factor-α-activated mesenchymal stem cells accelerate wound healing through vascular endothelial growth factor regulation in rats

Background Wounds are areas of physical or thermal damage of the epithelial layer of skin or mucosa. The wound healing process consists of hemostasis, inflammation, proliferation, and remodeling. Mesenchymal stem cells (...

Combination of three laboratory data as predictor of severe dengue in adults : a retrospective cohort study

Introduction Skin hydration decreases with aging. Aquaporin-3 (AQP3) is a major protein that plays a role in skin hydration, therefore it is a novel target for skin moisturizing treatment. Retinoic acid (RA) as a well-kn...

Hormonal contraception increases risk of breast tumor based on clinical breast examination among adult women

Background In Indonesia, cancer prevalence according to the Basic Health Research 2013 was 1.4 per 1000 inhabitants and the most common cancer in hospitalized patients in 2010 was breast cancer (28.7%). Hormonal contrace...

New tuberculosis vaccine to support tuberculosis elimination

The Sustainable Development Goals have prioritized ending the epidemic of tuberculosis by 2030.(1) Around one-third of the world population is infected with Mycobacterium tuberculosis (MTBC), but is asymptomatic, a condi...

Download PDF file
  • EP ID EP375618
  • DOI 10.18051/UnivMed.2017.v36.221-227
  • Views 222
  • Downloads 0

How To Cite

Mirna Widiyanti, Reynold Ubra, Eva Fitriana (2017). Low body mass index increases risk of anemia in patients with HIV-AIDS receiving antiretroviral therapy. Universa Medicina, 36(3), 221-227. https://europub.co.uk/articles/-A-375618