Low molecular weight protamine as nontoxic heparin/low molecular weight heparin antidote (III): Preliminary in vivo evaluation of efficacy and toxicity using a canine model
Journal Title: The AAPS Journal - Year 2001, Vol 3, Issue 3
Abstract
Authors and Affiliations
Li-Chien Chang, Shirley Wrobleski, Thomas W. Wakefield, Lai Ming Lee, Victor C. Yang
Targeting TRPV1 as an Alternative Approach to Narcotic Analgesics to Treat Chronic Pain Conditions
In spite of intense research efforts and after the dedicated Decade of Pain Control and Research, there are not many alternatives to opioid-based narcotic analgesics in the therapeutic armamentarium to treat chronic pain...
Prediction of Human Glomerular Filtration Rate from Preterm Neonates to Adults: Evaluation of Predictive Performance of Several Empirical Models
The objective of this study was to evaluate the predictive performance of several allometric empirical models (body weight dependent, age dependent, fixed exponent 0.75, a data-dependent single exponent, and maturation m...
RNAi-directed inhibition of DC-SIGN by dendritic cells: Prospects for HIV-1 therapy
Drug-resistant human immunodeficiency virus (HIV) infections are increasing globally, especially in North America. Therefore, it is logical to develop new therapies directed against HIV binding molecules on susceptible h...
Assessment of the Impact of Dosing Time on the Pharmacokinetics/Pharmacodynamics of Prednisolone
Prednisolone is widely used for the treatment of inflammation and auto-immune diseases. It exhibits nonlinear pharmacokinetics (PK); and its induced systemic effects (pharmacodynamics (PD)) are commonly evaluated with tw...
Impact of Osmotically Active Excipients on Bioavailability and Bioequivalence of BCS Class III Drugs
SAPP is commonly used as a food additive and mostly found in bakery products (40). SAPP can also be employed as an excipient for effervescent formulations to provide rapid disintegration of pharmaceutical products. In a...