Medicinal plant products targeting quorum sensing for combating bacterial infections
Journal Title: Asian Pacific Journal of Tropical Medicine - Year 2017, Vol 10, Issue 8
Abstract
Traditional treatment of infectious diseases is based on compounds that aim to kill or inhibit bacterial growth. The bacterial resistance against antibiotics is a serious issue for public health. Today, new therapeutic targets other than the bacterial wall were deciphered. Quorum sensing or bacterial pheromones are molecules called auto-inducer secreted by bacteria to regulate some functions such as antibiotic resistance and biofilms formation. This therapeutic target is well-studied worldwide, nevertheless the scientific data are not updated and only recent researches started to look into its potential as a target to fight against infectious diseases. A major concern with this approach is the frequently observed development of resistance to antimicrobial compounds. Therefore, this paper aims to provide a current overview of the quorum sensing system in bacteria by revealing their implication in biofilms formation and the development of antibiotic resistance, and an update on their importance as a potential target for natural substances.
Authors and Affiliations
Abdelhakim Bouyahya
Keywords
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- EP ID EP279737
- DOI 10.1016/j.apjtm.2017.07.021
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